Most Read Articles
Jairia Dela Cruz, 15 Apr 2019
Use of oral contraceptives (OC) confers some protection against bone loss in patients with anorexia nervosa (AN), a study has found. Areal bone mineral density preservation improves with longer durations of OC use and shorter delays between disease onset and OC initiation, and appears to be most pronounced in patients more severe forms of AN.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 16 Nov 2019

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.

Pearl Toh, 17 Apr 2019
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.

Novel selective cathepsin K inhibitor safely reduces bone, cartilage progression in osteoarthritis

08 Jan 2020

The new selective cathepsin K inhibitor MIV-711 does not perform better than placebo in easing osteoarthritic pain, a study has shown. However, it substantially decreases bone and cartilage progression with a reassuring safety profile.

The MIV-711 showed no statistically significant changes in numerical rating scale (NRS) pain scores as compared with placebo (MIV-711 100 mg/d, –1.7; MIV-711 200 mg/d, –1.5; placebo, –1.4).

Nonetheless, its use resulted in a significant decrease in medial femoral bone area progression (p=0.002 for 100 mg/d; p=0.004 for 200 mg/d) and medial femoral cartilage thinning (p=0.023 for 100 mg/d; p=0.125 for 200 mg/d), as well as a substantial reduction in bone and cartilage biomarker levels.

Six participants experienced serious adverse events (three in the 100-mg/d group, two in the 200-mg/d group and one in the placebo group), but none of these events were treatment-related.

“This treatment may merit further evaluation as a disease-modifying osteoarthritis drug,” the authors said.

A total of 244 participants with primary knee osteoarthritis, Kellgren–Lawrence grade 2 or 3, and an nRS pain score of 4–10 were included in this 26-week randomized, double-blind, placebo-controlled phase IIa study with a 26-week open-label safety extension substudy.

Participants were randomly assigned to received MIV-700 100 (n=82) or 200 (n=81) mg daily, or matched placebo (n=77). Forty-six participants who initially received 200 mg/d and four who received placebo were given 200 mg of MIV-700 daily during the extension substudy.

The trial was limited by its relatively short duration.

“MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone and cartilage in preclinical osteoarthritis models,” according to the authors.

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Most Read Articles
Jairia Dela Cruz, 15 Apr 2019
Use of oral contraceptives (OC) confers some protection against bone loss in patients with anorexia nervosa (AN), a study has found. Areal bone mineral density preservation improves with longer durations of OC use and shorter delays between disease onset and OC initiation, and appears to be most pronounced in patients more severe forms of AN.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 16 Nov 2019

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.

Pearl Toh, 17 Apr 2019
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.