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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
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Novel scoring tool predicts 1-year mortality in elderly cancer patients

01 May 2020

MetaGENUA, a novel six-variable scoring scheme, can reliably predict mortality in elderly cancer patients, a recent study has shown.

Researchers conducted a single-centre, prospective analysis of 162 elderly cancer patients (mean age, 78±5.5 years; 57 percent female) who underwent a comprehensive geriatric assessment (CGA) before receiving treatment. The outcome of interest was 1-year mortality.

More than half of the participants had impairments in at least three clinical domains of the CGA and were identified as frail. This was mostly driven by multimorbidity, a heightened risk of malnutrition and an initial decline in instrumental activities of daily living (IADL).

Twenty-two patients died within the first year of surgery, yielding an overall 1-year mortality rate of 13.5 percent. Seventy-seven percent of the deaths were related to cancer.

Six variables made up the final prediction model: age, IADL, cancer stage, malnutrition risk, geriatric depression scale scores and cumulative illness rating scale scores. Taken together, the model had an overall accuracy of 0.65 in the training cohort. There was also relative ease of use, with an estimated mean time of MetaGENUA score generation of 20 minutes.

Upon validation, the model yielded a sensitivity of 0.59 and a specificity of 0.86. The resulting area under the receiver operator characteristic curve was 0.72 (95 percent confidence interval, 0.55–0.87).

“We anticipate that the routine use of MetaGENUA will allow a more rational administration of cancer treatments and translate into improved clinical outcomes both in terms of oncological and geriatric endpoints,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.