Most Read Articles
24 May 2020
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 2 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 3 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.

Novel scoring tool predicts 1-year mortality in elderly cancer patients

01 May 2020

MetaGENUA, a novel six-variable scoring scheme, can reliably predict mortality in elderly cancer patients, a recent study has shown.

Researchers conducted a single-centre, prospective analysis of 162 elderly cancer patients (mean age, 78±5.5 years; 57 percent female) who underwent a comprehensive geriatric assessment (CGA) before receiving treatment. The outcome of interest was 1-year mortality.

More than half of the participants had impairments in at least three clinical domains of the CGA and were identified as frail. This was mostly driven by multimorbidity, a heightened risk of malnutrition and an initial decline in instrumental activities of daily living (IADL).

Twenty-two patients died within the first year of surgery, yielding an overall 1-year mortality rate of 13.5 percent. Seventy-seven percent of the deaths were related to cancer.

Six variables made up the final prediction model: age, IADL, cancer stage, malnutrition risk, geriatric depression scale scores and cumulative illness rating scale scores. Taken together, the model had an overall accuracy of 0.65 in the training cohort. There was also relative ease of use, with an estimated mean time of MetaGENUA score generation of 20 minutes.

Upon validation, the model yielded a sensitivity of 0.59 and a specificity of 0.86. The resulting area under the receiver operator characteristic curve was 0.72 (95 percent confidence interval, 0.55–0.87).

“We anticipate that the routine use of MetaGENUA will allow a more rational administration of cancer treatments and translate into improved clinical outcomes both in terms of oncological and geriatric endpoints,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
24 May 2020
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 2 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 3 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.