Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Novel risk model predicts 6-month post-AMI mortality in older adults

13 Jan 2020

A new risk model for predicting 6-month mortality for older adults hospitalized with acute myocardial infarction (AMI) has been developed, demonstrating good calibration and discrimination, reports a recent study.

The model may prove useful in decision making at hospital discharge, the researchers said.

This prospective cohort study was conducted in 94 hospitals across the US and enrolled 3,006 persons aged 75 years who were hospitalized with AMI and discharged alive. Either direct measurement or self-report was employed to assess functional impairments during hospitalization. A chart review was performed to ascertain clinical variables associated with mortality in prior risk models.

The researchers selected 72 candidate variables for inclusion. They used backward selection and Bayesian model averaging to derive (n=2,004) and validate (n=1,002) a model for 6-month post-AMI mortality.

Of the participants (mean age, 81.5 years; 44.4 percent women; 10.5 percent nonwhite), 266 died (8.8 percent) within 6 months. The final risk model included 15 variables, of which four (ie, hearing impairment, mobility impairment, weight loss and lower patient-reported health status) were not included in previous risk models.

The model was well calibrated (Hosmer–Lemeshow p>0.05) and had good discriminatory ability (area under the curve for the validation cohort, 0.84). The addition of functional impairments led to significant improvements in model performance, as shown by category-free net reclassification improvement indices of 0.21 (p=0.008) for hearing impairment and 0.26 (p<0.001) for mobility impairment.

The new model, however, was not validated externally, according to the researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.