Most Read Articles
Yesterday
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Taking 10 resting blood pressure (BP) readings daily for 2 days provides a reliable, stable representation of patients’ resting systolic (S)BP and diastolic (D)BP, according to a study. This approach shows that the current home BP monitoring protocol of twice-daily readings for 4–7 days may be trimmed down to just 48 hours.
Pearl Toh, 12 Apr 2018
A smartwatch photoplethysmography coupled with a mobile application using a machine learning algorithm can passively and accurately detect atrial fibrillation (AF) in patients undergoing cardioversion, albeit with less accuracy in ambulatory individuals with self-reported AF, a proof-of-concept study shows.
Pearl Toh, 6 days ago
Impaired endothelial-dependent microvascular reactivity appears to be predictive of albuminuria progression in Asian patients with type 2 diabetes (T2D) who have normal urine albumin levels at baseline, but not in those with microalbuminuria, a prospective longitudinal cohort study suggests.

Novel MRI neuroimaging techniques enhance Alzheimer’s characterization

Jackey Suen
09 Dec 2015

Recent advances in MRI techniques allow faster and more accurate neuroimaging, which greatly facilitates the characterization of brain structure and function associated with normal ageing and Alzheimer’s disease (AD).

“Better characterization of AD is needed as nearly all [99.6 percent] clinical trials of AD therapies showed negative results,” said Professor Lawrence Frank of the University of California, San Diego, CA, USRecent advances in MRI techniques allow faster and more accurate neuroimaging, which greatly facilitates the characterization of brain structure and function associated with normal ageing and Alzheimer’s disease (AD). “Better characterization of AD is needed as nearly all [99.6 percent] clinical trials of AD therapies showed negative results,” said Professor Lawrence Frank of the University of California, San Diego, CA, US, at the International Symposium on Cognitive and Developmental Neuroscience: From Molecular to Behaviour organized by the Brain and Mind Institute, Chinese University of Hong Kong. [Alzheimers Res Ther 2014;6:37]

Frank and his team recently developed two novel MRI approaches to enhance the imaging of brain morphology, neural connectivity and functional connectivity, which can potentially improve the characterization of changes in brain structure and function in patients with AD.

“The current method used in brain shape imaging involves data collection, surface definition, segmentation of data, surface fitting and inflation to fit coefficient. The whole process is laborious, time-consuming and error-prone,” noted Frank. “Our novel method analyzes the entire data volume automatically, obviating the steps of segmentation, inflation and surface fitting. It significantly reduces computational time and errors while providing a more detailed quantitative description of the brain.” [Neuroimage 2014;92:156-168]

“We also introduced a new computational technique which allows more accurate and complete estimations for characterization of neural connections in the brain using magnetic resonance diffusion tensor imaging, as well as mapping of functional connectivity using functional MRI,” he added. [IEEE Trans Med Imaging 2015;34:1177-1193]

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Most Read Articles
Yesterday
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Taking 10 resting blood pressure (BP) readings daily for 2 days provides a reliable, stable representation of patients’ resting systolic (S)BP and diastolic (D)BP, according to a study. This approach shows that the current home BP monitoring protocol of twice-daily readings for 4–7 days may be trimmed down to just 48 hours.
Pearl Toh, 12 Apr 2018
A smartwatch photoplethysmography coupled with a mobile application using a machine learning algorithm can passively and accurately detect atrial fibrillation (AF) in patients undergoing cardioversion, albeit with less accuracy in ambulatory individuals with self-reported AF, a proof-of-concept study shows.
Pearl Toh, 6 days ago
Impaired endothelial-dependent microvascular reactivity appears to be predictive of albuminuria progression in Asian patients with type 2 diabetes (T2D) who have normal urine albumin levels at baseline, but not in those with microalbuminuria, a prospective longitudinal cohort study suggests.