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Pearl Toh, 26 Nov 2020
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Novel lipid-lowering drug halts development, progression of diabetes

07 Sep 2020

Bempedoic acid, a novel drug used to lower the bad cholesterol, reduces the risk of developing new-onset diabetes or its progression, according to the results of a meta-analysis.

Researchers searched multiple online databases for studies evaluating the effect of bempedoic acid therapy on new-onset or worsening diabetes with a minimum of 4 weeks of follow-up. They used the fixed-effects model and performed a meta-analysis according to PRISMA guidelines.

The meta-analysis included five randomized controlled trials of bempedoic acid. The total population comprised 3,629 patients, among whom 2,419 were allocated to receive bempedoic acid while 1,210 were allocated to the respective control arms.

Compared with control therapy, bempedoic acid was associated with a significant decrease in the risk of new-onset or worsening diabetes (odds ratio, 0.66, 95 percent confidence interval, 0.48–0.90; I2, 0 percent).

Additional investigation is warranted to confirm this finding.

Bempedoic acid is a small molecule inhibitor of ATP-citrate lyase, administered orally for the treatment of hyperlipidaemia. Its protective effect on diabetes risk may be related to AMP-activated protein kinase (AMPK), since bempedoic acid plays a dual role in both activation of hepatic AMPK signalling pathway and inhibitory activity against hepatic ATP-citrate lyase. [Curr Opin Lipidol 2014;25:309-315; J Lipid Res 2013;54:134-151]

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Most Read Articles
4 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.