Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

Nonobese postmenopausal women with diabetes at risk of kidney cancer

30 Aug 2020

Diabetes bears an increased hazard of developing kidney cancer among postmenopausal women, but this association is only limited to those without obesity, a study has shown.

The analysis included 36,975 women (mean age, 61.7 years), of whom 2,353 (6.4 percent) reported having diabetes at baseline. An additional 3,140 (8.5 percent) women developed diabetes over 25 years of follow-up.

Overall, women with vs without diabetes had a slightly higher body mass index (BMI) and waist-to-hip ratio (WHR), were more likely to have hypertension and use diuretics, and were less likely to engage in high/moderate physical activity and consume alcohol, calcium, and vitamin E.

In age-adjusted Cox proportional hazards model, diabetes was associated with an increased risk of kidney cancer (hazard ratio [HR], 1.76, 95 percent confidence interval [CI], 1.26–1.45). However, this association disappeared after further adjustments for BMI, WHR, hypertension, physical activity, diuretic use, pack-years of smoking, alcohol intake, and total caloric intake (HR, 1.35, 95 percent CI, 0.94–1.94).

Interestingly, the risk increase seen for kidney cancer persisted among diabetic women with a waist circumference <34.6 inches (HR, 2.18, 95 percent CI, 1.08–4.38) or with BMI <30 kg/m2 (HR, 1.82, 95 percent CI, 1.10–3.00).

While the present data should be validated in a larger sample, researchers stressed that nonobese postmenopausal women who develop new-onset diabetes should undergo a more thorough surveillance for cancer.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.