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Noninvasive risk score shows value in predicting dysglycaemia

15 Feb 2020

A new noninvasive risk scoreincorporating factors such as waist circumference (WC), age, sex, and histories of hyperglycaemia and diabetes in the family reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.

The study included 1,403 adults known to be free of diabetes. A questionnaire was administered to collect demographic, dietary, medical history and lifestyle factors, and the results of these were combined with laboratory variables to produce a specified risk score.

Laboratory tests found that 69 participants were diabetic and that another 259 were prediabetic. Majority of these participants were dysglycaemic by virtue of the 1-hour plasma glucose (60 percent) or glycated haemoglobin (59 percent) criteria. Dysglycaemia was numerically more common in males and increased in prevalence with age.

Univariate analysis found that body mass index (BMI), WC, antihypertensive medication, hyperglycaemia history, family history, low physical activity and short sleep were potential predictors of dysglycaemia risk in the study cohort. Diet, on the other hand, including intake levels of fruits and vegetables, was not.

The final model was named Saudi Diabetes Risk Score (SARDISC) and consisted of five variables: sex, age, WC, history of hyperglycaemia and family history of diabetes. WC and BMI showed strong collinearity such that the latter factor was excluded from the model. Sensitivity analysis backed this up, showing highly similar results from both anthropometric variables.

The area under the receiver operating characteristic curve of SARDISC for predicting dysglycaemia was 0.76 (95 percent confidence interval, 0.73–0.79).

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Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.