Most Read Articles
Tristan Manalac, 09 Sep 2018
Structured and remote patient management interventions are effective in reducing all-cause mortality and the number of days lost due to unplanned hospitalizations in heart failure patients, according to a recent study.
Radha Chitale, 08 Apr 2016
A trial assessing the implantable CardioFit® device designed to stimulate the parasympathetic nervous system in heart failure patients failed to meet its primary endpoints – reducing the rate of hospitalization due to heart failure or death by any cause.
27 Aug 2018
Obese men appear to have better ST-elevation myocardial infarction (STEMI) prognoses than their normal weight counterparts, regardless of metabolic syndrome status, a recent study has shown.
27 Jul 2018
There appears to be no association between intraduodenal administration of the artificial sweetener sucralose in healthy older patients and changes in blood pressure (BP) or superior mesenteric artery (SMA) blood flow, reports a study.

Nonalcoholic fatty liver disease ups risk of diabetes mellitus

11 Apr 2018

In nonobese adults, the presence of nonalcoholic fatty liver disease (NAFLD) signals a higher risk for eventual diabetes mellitus (DM) regardless of metabolic syndrome, a recent study has shown.

The study included 2,920 adults who self-referred for a routine health check-up from January to December 2000. Ultrasonography was performed to determine NAFLD status, and Cox proportional hazards regression models were used to evaluate the risk of hypertension and DM incidence according to participant phenotypes.

Over a median follow-up of 5.1 years, 193 participants developed DM, corresponding to a 6.9-percent incidence rate. Both NAFLD patients who were obese (hazard ratio [HR], 2.89; 95 percent CI, 1.73–4.83; p<0.001) and nonobese (HR, 2.69; 1.72–4.20; p<0.001) had significantly elevated risks of DM.

In addition, DM was significantly more likely in obese participants without NAFLD (HR, 1.92; 1.10–3.36; p=0.022).

In 2,757 participants, 445 developed hypertension over the same follow-up period, resulting in an incidence rate of 16.1 percent. Fully adjusted analysis showed that obese participants with NAFLD had a significantly higher risk of hypertension than their nonobese, non-NAFLD counterparts (HR, 1.76; 1.27–2.44; p=0.001).

The findings of the present study show that NAFLD is a particularly sensitive indicator of potential insulin resistance, said researchers, noting that patients with the condition may benefit from regular screening.

“Screening may provide the opportunity to address insulin resistance early, with lifestyle modification and medical interventions to reduce the risk of progression to DM,” they added.

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Most Read Articles
Tristan Manalac, 09 Sep 2018
Structured and remote patient management interventions are effective in reducing all-cause mortality and the number of days lost due to unplanned hospitalizations in heart failure patients, according to a recent study.
Radha Chitale, 08 Apr 2016
A trial assessing the implantable CardioFit® device designed to stimulate the parasympathetic nervous system in heart failure patients failed to meet its primary endpoints – reducing the rate of hospitalization due to heart failure or death by any cause.
27 Aug 2018
Obese men appear to have better ST-elevation myocardial infarction (STEMI) prognoses than their normal weight counterparts, regardless of metabolic syndrome status, a recent study has shown.
27 Jul 2018
There appears to be no association between intraduodenal administration of the artificial sweetener sucralose in healthy older patients and changes in blood pressure (BP) or superior mesenteric artery (SMA) blood flow, reports a study.