Most Read Articles
Elvira Manzano, 22 Jan 2018
A new study has shown an independent association between periodontal disease and incident stroke risk. What’s interesting is routine dental care can attenuate the stroke risk.
Stephen Padilla, 05 May 2017
It appears that long-term dietary consumption of foods containing gluten does not increase the risk of coronary heart disease (CHD), suggests a recent study. However, the avoidance of gluten may result in a reduced intake of beneficial whole grains, which may affect cardiovascular risk.
Audrey Abella, 17 Dec 2018
Low rates of cardiovascular (CV) or major bleeding complications were observed among octogenarians who were receiving active NOAC* therapy, suggesting that long-term anticoagulation with NOACs may result in a good risk-benefit ratio in this patient subgroup, according to data presented at ASH 2018.
Pank Jit Sin, 01 Feb 2019
Single pill combination (SPC) therapy is increasingly accepted and helps to overcome some of the problems associated with multipharmacy and compliance, says an expert. 

Nonalcoholic fatty liver disease ups risk of diabetes mellitus

11 Apr 2018

In nonobese adults, the presence of nonalcoholic fatty liver disease (NAFLD) signals a higher risk for eventual diabetes mellitus (DM) regardless of metabolic syndrome, a recent study has shown.

The study included 2,920 adults who self-referred for a routine health check-up from January to December 2000. Ultrasonography was performed to determine NAFLD status, and Cox proportional hazards regression models were used to evaluate the risk of hypertension and DM incidence according to participant phenotypes.

Over a median follow-up of 5.1 years, 193 participants developed DM, corresponding to a 6.9-percent incidence rate. Both NAFLD patients who were obese (hazard ratio [HR], 2.89; 95 percent CI, 1.73–4.83; p<0.001) and nonobese (HR, 2.69; 1.72–4.20; p<0.001) had significantly elevated risks of DM.

In addition, DM was significantly more likely in obese participants without NAFLD (HR, 1.92; 1.10–3.36; p=0.022).

In 2,757 participants, 445 developed hypertension over the same follow-up period, resulting in an incidence rate of 16.1 percent. Fully adjusted analysis showed that obese participants with NAFLD had a significantly higher risk of hypertension than their nonobese, non-NAFLD counterparts (HR, 1.76; 1.27–2.44; p=0.001).

The findings of the present study show that NAFLD is a particularly sensitive indicator of potential insulin resistance, said researchers, noting that patients with the condition may benefit from regular screening.

“Screening may provide the opportunity to address insulin resistance early, with lifestyle modification and medical interventions to reduce the risk of progression to DM,” they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elvira Manzano, 22 Jan 2018
A new study has shown an independent association between periodontal disease and incident stroke risk. What’s interesting is routine dental care can attenuate the stroke risk.
Stephen Padilla, 05 May 2017
It appears that long-term dietary consumption of foods containing gluten does not increase the risk of coronary heart disease (CHD), suggests a recent study. However, the avoidance of gluten may result in a reduced intake of beneficial whole grains, which may affect cardiovascular risk.
Audrey Abella, 17 Dec 2018
Low rates of cardiovascular (CV) or major bleeding complications were observed among octogenarians who were receiving active NOAC* therapy, suggesting that long-term anticoagulation with NOACs may result in a good risk-benefit ratio in this patient subgroup, according to data presented at ASH 2018.
Pank Jit Sin, 01 Feb 2019
Single pill combination (SPC) therapy is increasingly accepted and helps to overcome some of the problems associated with multipharmacy and compliance, says an expert.