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Nonalcoholic fatty liver disease negatively affects quality of life

20 May 2020

Patients with nonalcoholic fatty liver disease (NAFLD), including those without advanced fibrosis, appear to have lower quality of life (QOL), as reported in a study.

Researchers examined 341 NAFLD patients who completed the short form 36 (SF-36) questionnaire. They assessed body composition and liver fibrosis using bioelectrical impedance and transient elastography, respectively. Advanced fibrosis was defined as liver stiffness measurement (LSM) of 12.1 kPa.

Scores from all eight SF-36 domains were negatively associated with percent body fat and positively associated with lean body mass among patients with NAFLD.

On multivariable analysis, SF-36 physical functioning domain score showed a negative association with type 2 diabetes, body mass index, and LSM. Additionally, the score was positively associated with lean body mass and level of alanine aminotransferase.

Compared with individuals with chronic medical illnesses and the general population obtained from the published literature, NAFLD patients with or without advanced fibrosis had significantly lower mean QOL scores.

The present data highlight the influence of body composition on QOL in patients with NAFLD, according to the researchers. Additional investigation in needed to establish whether interventions to improve body composition can improve QOL in this population.

QOL assessment is useful because this measure sheds light on the overall burden of NAFLD from the patient’s perspective. In addition, there may be other important implications of poor QOL, including healthcare utilization, productivity and mortality. [Hepatology 2009;49:1904-1912]

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).