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Elaine Soliven, 27 Dec 2018
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Nocturnal hypertension in high-risk mid-pregnancies predicts pre-eclampsia/eclampsia

11 Jan 2019

A recent study suggests that nocturnal hypertension at high-risk mid-pregnancy is common and strongly predicts pre-eclampsia/eclampsia (PEEC). Such risk was two times higher in women not taking acetylsalicylic acid (ASA).

Eighty-seven women (mean age 31±7 years) with 23±2 weeks of pregnancy were included in the study. The corresponding prevalence of office and ambulatory blood pressure monitoring (ABPM) hypertension was 13.8 percent and 40.2 percent. There was a low concordance between these two diagnoses of hypertension (κ, 0.170; p=0.044).

Nocturnal hypertension was more frequent than diurnal hypertension (35.6 percent vs 26.4 percent). Nocturnal hypertension significantly elevated the relative risk of PEEC (odds ratio [OR], 5.32; 95 percent CI, 1.48–19.10).

PEEC risk associated with diurnal hypertension was not statistically significant. When both diurnal and nocturnal hypertension were included in the same model, only the latter significantly predicted PEEC (p=0.012). Furthermore, women not taking ASA had higher relative risk attributed to nocturnal hypertension (OR, 11.40; 2.35–55.25).

Women coursing high-risk mid-pregnancies participated in this study, which sought to test whether hypertension detected by ABPM was a useful predictor for PEEC. Office BP, taken by a specialized nurse after a 15-min interview, was estimated as the mean of three values. Office hypertension was defined as 140/90 mm Hg. An ABPM was initiated immediately after.

Diurnal hypertension referred to ABPM 135/85 mm Hg during daily activities, while nocturnal hypertension was defined as ABPM 120/70 mm Hg during night rest. The investigators used logistic regression to estimate the adjusted PEEC risk.

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Most Read Articles
Elaine Soliven, 27 Dec 2018
A lifestyle intervention programme focusing on healthy habits was associated with weight loss and better disease-free survival (DFS) among early breast cancer survivors, according to the SUCCESS C* study presented at SABCS 2018.
23 Dec 2018
TX-001HR, a fixed-dose combination of oestradiol and progesterone, yields clinically meaningful improvements in the frequency and/or severity vasomotor symptoms in menopausal women with a uterus, according to a study.
22 Dec 2018
Breastfeeding for more than 6 months after birth appears to be independently associated with a long-term decrease in waist circumference, reports a recent study.
Elaine Soliven, 11 Jul 2018

Adding bevacizumab to platinum-based chemotherapy significantly improves progression-free survival (PFS) in patients with recurrent ovarian cancer who were previously treated with first-line bevacizumab, according to the MITO16B - MaNGO OV2B - ENGOT OV17* study presented at ASCO 2018.