Most Read Articles
Pearl Toh, 5 days ago
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4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
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Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

No link between vitamin D and metabolic syndrome among female SLE patients

06 Nov 2019

Higher serum 25‐hydroxyvitamin D (25(OH)D) concentrations confer no protective benefit in terms of metabolic syndrome in nondiabetic women with systemic lupus erythematosus (SLE), a study suggests.

The study included 160 nondiabetic SLE women (mean age, 43.3 years), most of whom had mild disease activity (median SLEDAI‐2K score, 2; median disease duration, 11 years). The proportion of patients with an SDI ≥1 was 33.1 percent. Eighty-eight percent of the participants were taking prednisone, while 65 percent were on antimalarial therapy. Nearly half of the patients (49 percent) used concurrent immunosuppressive therapy.

Vitamin D deficiency (<20 ng/mL) was found in 40.6 percent of participants, while vitamin D insufficiency (20–29 ng/mL) was 49.4 percent. Mean serum 25(OH)D concentrations did not differ significantly in patients with neuropsychiatric (23.2 ng/mL), haematological (22.0 ng/mL) and nephritis lupus (21.7 ng/mL) manifestations.

About half of the participants (49.3 percent) had metabolic syndrome. The likelihood of having metabolic syndrome decreased with increasing quartiles of 25(OH)D concentrations (p-trend=0.03). Compared with the lowest 25(OH)D quartile, the highest quartile was associated with 60-percent reduced odds of having metabolic syndrome (odds ratio [OR], 0.4, 95 percent confidence interval, 0.2–0.9; p=0.04). Similarly, the odds of having elevated hypertriglyceridemia decreased according to increasing quartiles of 25(OH)D concentrations (p-trend=0.036).

However, this association between 25(OH)D concentrations and MetS and its individual components disappeared after controlling for body mass index and smoking.

Researchers underscored a need for large prospective studies to establish the roles of 25(OH)D in the incidence of metabolic syndrome in SLE patients.

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Most Read Articles
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.