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02 Nov 2019
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No link between vitamin D and metabolic syndrome among female SLE patients

6 days ago

Higher serum 25‐hydroxyvitamin D (25(OH)D) concentrations confer no protective benefit in terms of metabolic syndrome in nondiabetic women with systemic lupus erythematosus (SLE), a study suggests.

The study included 160 nondiabetic SLE women (mean age, 43.3 years), most of whom had mild disease activity (median SLEDAI‐2K score, 2; median disease duration, 11 years). The proportion of patients with an SDI ≥1 was 33.1 percent. Eighty-eight percent of the participants were taking prednisone, while 65 percent were on antimalarial therapy. Nearly half of the patients (49 percent) used concurrent immunosuppressive therapy.

Vitamin D deficiency (<20 ng/mL) was found in 40.6 percent of participants, while vitamin D insufficiency (20–29 ng/mL) was 49.4 percent. Mean serum 25(OH)D concentrations did not differ significantly in patients with neuropsychiatric (23.2 ng/mL), haematological (22.0 ng/mL) and nephritis lupus (21.7 ng/mL) manifestations.

About half of the participants (49.3 percent) had metabolic syndrome. The likelihood of having metabolic syndrome decreased with increasing quartiles of 25(OH)D concentrations (p-trend=0.03). Compared with the lowest 25(OH)D quartile, the highest quartile was associated with 60-percent reduced odds of having metabolic syndrome (odds ratio [OR], 0.4, 95 percent confidence interval, 0.2–0.9; p=0.04). Similarly, the odds of having elevated hypertriglyceridemia decreased according to increasing quartiles of 25(OH)D concentrations (p-trend=0.036).

However, this association between 25(OH)D concentrations and MetS and its individual components disappeared after controlling for body mass index and smoking.

Researchers underscored a need for large prospective studies to establish the roles of 25(OH)D in the incidence of metabolic syndrome in SLE patients.

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Most Read Articles
02 Nov 2019
Treatment with the selective serotonin reuptake inhibitor escitalopram may confer beneficial effects on neuroticism, possibly by inducing reduction in anxiety, a recent study has shown.
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.