Most Read Articles
4 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
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No link between thrombopoietin receptor agonists use and portal vein thrombosis in CLD

13 Jan 2019

Thrombopoietin receptor agonists (TPORAs) show no clear association with portal vein thrombosis (PVT) when used to treat patients with chronic liver disease (CLD), reports a recent meta-analysis.

A pooled analysis of four studies (n=1,953 CLD patients) showed that there was no significant increase in the incidence of PVT in patients treated with TPORAs compared with those who received placebo (odds ratio [OR], 2.8; 95 percent CI, 0.97–8.16; p=0.055).

The TPORAs tested in the studies were eltrombopag, avatrombopag and lusutrombopag. While there were no significant publication bias (p=0.4) and evidence of heterogeneity (p=0.718) among the studies, the correlation between PVT and TPORA use achieved statistical significance when analysis was restricted to patients treated with eltrombopag (OR, 3.8; 1.14–13.2; p=0.03).

Moreover, in two studies including 1,727 patients, the rates of arterial and venous thromboembolic events were 3.6 percent and 1.1 percent in those who received eltrombopag or placebo, respectively. This corresponded to a significant difference (OR, 3.4; 1.5–7.7; p=0.003).

In a subsequent analysis including three studies (n=514 patients), there was no significant link between TPORA use and PVT incidence in patients with liver disease and thrombocytopaenia undergoing elective invasive procedures (vs placebo: 2.8 percent vs 0.9 percent; OR, 2.6; 0.6–11.6; p=0.212). Heterogeneity and publication bias were likewise nonsignificant.

In the present meta-analysis, the databases of PubMed, SCOPUS, Cochrane and ISI Web of Science were accessed. Aside from case reports, commentaries, review articles and animal studies, papers that did not include an untreated control group were ineligible for inclusion.

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Most Read Articles
4 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
2 days ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
17 Aug 2019
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
6 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.