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No adverse outcomes with metformin in women with GDM

Elaine Soliven
12 Jan 2018

Use of metformin during the first trimester of pregnancy showed no significant maternal or foetal adverse outcomes in women with gestational diabetes mellitus (GDM), according to a study presented at IDF 2017.

The researchers retrospectively analysed 540 pregnant women (mean age 29 years). Participants were divided into three groups according to the prescribed medications: group A (n=186; metformin in the first trimester), group B (n=203; metformin after the first trimester), and group C (n=151; insulin in any trimester). Patients were diagnosed with GDM at a mean gestational age of 10, 23, and 24 weeks in groups A, B, and C, respectively. The study’s primary outcome was a composite of neonatal hypoglycaemia, respiratory distress, need for phototherapy, birth trauma, 5-minute APGAR score <7, and prematurity. [IDF 2017, abstract P-0972]

Results of the primary composite outcomes did not differ significantly between groups A and B (odds ratio [OR], 1.738, 95 percent confidence interval [CI], 0.657–4.597) and groups A and C (OR, 1.717, 95 percent CI, 0.715–4.119).

Of the 184 participants on metformin, 53.22 and 41.87 percent required supplemental insulin in groups A and B, respectively.

However, a higher rate of preterm births was observed among patients in group A compared with groups B and C (9.67 percent vs 6.89 percent and 9.27 percent, respectively) as well as a higher rate of pregnancy loss (11 vs 1 and 2, respectively).

These findings were consistent with a previous study which showed higher rates of preterm birth among patients on metformin compared with insulin (12.1 percent vs 7.6 percent). [N Engl J Med 2008;358:2003-2015]

“Prematurity and foetal loss are two outcomes that warrant further critical evaluation in future studies in larger cohorts of GDM,” said lead author Dr Riddhi Das Gupta from the Department of Endocrinology, Diabetes & Metabolism at Christian Medical College in Vellore, India.

“[Nonetheless,] our findings strongly suggest that metformin … can prove to be a safe, effective, and cheaper modality of treatment in the first trimester of gestation in GDM mothers,” Das Gupta noted.
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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 13 Jan 2020
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
Stephen Padilla, 6 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).