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Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
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The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.

NLR predicts survival in polymyositis, dermatomyositis

06 Jan 2018

In patients with polymyositis or dermatomyositis, a high peripheral blood neutrophil-to-lymphocyte ratio (NLR) is independently associated with poorer overall survival, according to a study.

The researchers retrospectively reviewed the medical records of 197 patients (mean age at diagnosis 50.3±14.0 years; 65.0 percent female) with newly diagnosed polymyositis/dermatomyositis and recorded 26 deaths over the mean follow-up period of 33.6±33.9 months. The 5-year survival rate was 82 percent.

The log-transformed NLR and C-reactive protein-to-albumin ratio (CAR) were significantly higher in nonsurvivors (2.002±0.684 and –0.687±1.934, respectively) than in survivors (1.266±0.822 and s-2.403±2.244, respectively; p<0.001 for both).

Receiver operating curve (ROC) analysis showed that the optimal cutoff values for NLR and CAR were 4.775 and 0.0735, respectively. The corresponding mean areas under the ROC (AUC) for predicting mortality were 0.778 and 0.714.

Participants who were categorized into the high NLR and CAR groups according to the above cutoff values had significantly lower survival than their counterparts in the low NLR and CAR groups (p<0.001 for both).

In a subsequent multivariate analysis, adjusted for covariates through forward selection, both log-transformed (hazard ratio [HR], 2.216; 95 percent CI, 1.176–3.843; p<0.05) and elevated (HR, 5.201; 1.923–14.068; p=0.001) NLR were significant and independent predictors of lower overall mortality. Notably, the statistical relationship of CAR to survival was attenuated.

Other significant predictors included age >50 years (HR, 4.507; 1.289–15.733; p=0.018), hypoproteinemia (HR, 3.586; 1.333–9.650; p=0.01), and the presence of acute interstitial pneumonia (HR, 14.433; 6.076–34.286; p<0.001).

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.