Most Read Articles
Yesterday
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
2 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
2 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.

Nitrate intake linked to lower risk of early age-related macular degeneration

02 Nov 2018

Total nitrate intake, especially from vegetable sources, is associated with the incidence of early age-related macular degeneration (AMD), reports a new Australia study.

Using a semi-quantitative food frequency questionnaire, researchers evaluated the dietary intake of 2,856 adults. Follow-up after 15 years was conducted on 2,037 participants (mean age 63.8±8.3 years; 43.3 percent male). AMD incidence, the main study outcome, was assessed from retinal photographs.

At baseline, 12.4 percent of the participants were current smokers and more than half (59.4 percent) consumed at least one serving of fish per week. The incidence rates of early and late AMD were 15.3 percent and 4.1 percent, respectively.

Dividing participants into quartiles according to energy-adjusted daily nitrate intake, researchers showed that those in the third quartile (119.5–162.3 mg/day; adjusted odds ratio [OR], 0.61; 95 percent CI, 0.41–0.90; p<0.05) were significantly less likely to develop early AMD than those in the first quartile. No significant differences were observed for the second and fourth quartiles (p=0.19 for trend).

Stratified analysis according to nitrate source showed that the protective effect of being in the third quartile remained significant for vegetable nitrates (adjusted OR, 0.65; 0.44–0.96; p<0.05) but not for nonvegetable nitrates (adjusted OR, 0.79; 0.54–1.17).

On the other hand, nitrate consumption was consistently unrelated to the risk of late AMD, regardless of source of daily intake volume.  

Though future studies are still required to confirm and strengthen the present conclusions, the findings of the current study indicate that adopting diets rich in nitrate sources such as beetroot and green leafy vegetables may potentially be a simple strategy to minimize early AMD risk, said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
2 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
2 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.