Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
4 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
5 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.

Nitrate intake linked to lower risk of early age-related macular degeneration

02 Nov 2018

Total nitrate intake, especially from vegetable sources, is associated with the incidence of early age-related macular degeneration (AMD), reports a new Australia study.

Using a semi-quantitative food frequency questionnaire, researchers evaluated the dietary intake of 2,856 adults. Follow-up after 15 years was conducted on 2,037 participants (mean age 63.8±8.3 years; 43.3 percent male). AMD incidence, the main study outcome, was assessed from retinal photographs.

At baseline, 12.4 percent of the participants were current smokers and more than half (59.4 percent) consumed at least one serving of fish per week. The incidence rates of early and late AMD were 15.3 percent and 4.1 percent, respectively.

Dividing participants into quartiles according to energy-adjusted daily nitrate intake, researchers showed that those in the third quartile (119.5–162.3 mg/day; adjusted odds ratio [OR], 0.61; 95 percent CI, 0.41–0.90; p<0.05) were significantly less likely to develop early AMD than those in the first quartile. No significant differences were observed for the second and fourth quartiles (p=0.19 for trend).

Stratified analysis according to nitrate source showed that the protective effect of being in the third quartile remained significant for vegetable nitrates (adjusted OR, 0.65; 0.44–0.96; p<0.05) but not for nonvegetable nitrates (adjusted OR, 0.79; 0.54–1.17).

On the other hand, nitrate consumption was consistently unrelated to the risk of late AMD, regardless of source of daily intake volume.  

Though future studies are still required to confirm and strengthen the present conclusions, the findings of the current study indicate that adopting diets rich in nitrate sources such as beetroot and green leafy vegetables may potentially be a simple strategy to minimize early AMD risk, said researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
4 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
5 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.