Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Nipple-sparing mastectomy safe for breast cancer patients

08 Sep 2017

Nipple-sparing mastectomy is safe and yields high survival rates for breast cancer patients, a new study has shown. Moreover, in the period from 1998 to 2013, NSM has increased in prevalence.

The study accessed the Surveillance, Epidemiology and End Results database to obtain pertinent information of 2,440 breast cancer patients (median age 50 years) who underwent NSM between 1998 and 2013. Bilateral breast cancer patients and those with previous malignant tumours were excluded.

Study outcomes were cancer-specific survival (CSS) and overall survival (OS), and Cox proportional hazards regression was used to determine risk factors associated with the outcomes. Kaplan-Meier analysis was performed to estimate CSS and OS.

Before 2009, there were less than 100 annual cases of NSM. By 2013, the number of NSM cases increased to 779.

Over a median follow-up of 69 months, the 5-year CSS rate was 96.9 percent while the 10-year CSS rate was 94.9 percent. By comparison, the 5- and 10-year OS rates were 94.1 and 88.0 percent, respectively.

Multivariate analysis showed that African-American race (hazard ratio [HR], 3.21; 95 percent CI, 1.39 to 7.414), T1 stage (HR, 8.59; 1.06 to 69.34) and N1 to 3 stages (HR, 2.41; 1.06 to 5.48) were all independent risk factors for CSS.

On the other hand, age (HR, 4.81; 2.46 to 9.40) and T2 to 3 stages (HR, 2.78; 1.32 to 5.84) were the independent risk factors of OS.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.