Nipple-sparing mastectomy safe for breast cancer patients
Nipple-sparing mastectomy is safe and yields high survival rates for breast cancer patients, a new study has shown. Moreover, in the period from 1998 to 2013, NSM has increased in prevalence.
The study accessed the Surveillance, Epidemiology and End Results database to obtain pertinent information of 2,440 breast cancer patients (median age 50 years) who underwent NSM between 1998 and 2013. Bilateral breast cancer patients and those with previous malignant tumours were excluded.
Study outcomes were cancer-specific survival (CSS) and overall survival (OS), and Cox proportional hazards regression was used to determine risk factors associated with the outcomes. Kaplan-Meier analysis was performed to estimate CSS and OS.
Before 2009, there were less than 100 annual cases of NSM. By 2013, the number of NSM cases increased to 779.
Over a median follow-up of 69 months, the 5-year CSS rate was 96.9 percent while the 10-year CSS rate was 94.9 percent. By comparison, the 5- and 10-year OS rates were 94.1 and 88.0 percent, respectively.
Multivariate analysis showed that African-American race (hazard ratio [HR], 3.21; 95 percent CI, 1.39 to 7.414), T1 stage (HR, 8.59; 1.06 to 69.34) and N1 to 3 stages (HR, 2.41; 1.06 to 5.48) were all independent risk factors for CSS.
On the other hand, age (HR, 4.81; 2.46 to 9.40) and T2 to 3 stages (HR, 2.78; 1.32 to 5.84) were the independent risk factors of OS.