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Nine-valent human papillomavirus vaccine shows favourable safety profile

26 Dec 2019

Safety data of the 9-valent human papillomavirus vaccine (9vHPV) from the Vaccine Adverse Event Reporting System (VAERS) during the first 3 years of its licensure in the United States have shown neither new or unexpected safety signals, nor unusual reporting patterns for clinically important adverse events (AEs), as reported in a study. Furthermore, the safety profile of the vaccine is similar to that of its quadrivalent predecessor.

VAERS documented 7,244 AEs following receipt of 9vHPV. Of the AEs, 31.2 percent occurred among females and 21.6 percent among males; sex was not reported in 42.7 percent.

Majority (97.4 percent) of the AEs were nonserious, the most common being dizziness, syncope, headache and injection site reactions. These AEs occurred with similar frequency in men and women. There were two verified cases of deaths post-9vHPV treatment, although autopsy reports or death certificates suggested no evidence of a causal relationship with vaccination.

Roughly 28 million 9vHPV doses were administered during the study period, giving crude AE reporting rates of 259 reports per million doses distributed for all reports and 7 per million doses distributed for serious reports.

Empirical Bayesian data mining findings showed a significant association between 9vHPV and syncope and several types of vaccine administration errors (eg, administered at wrong age).

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Most Read Articles
4 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Yesterday
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
4 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).