Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Nine-valent HPV vaccine effective for more than 5 years

Dr Joslyn Ngu
09 Nov 2017

According to a study, the nine-valent Gardasil 9 vaccine is effective in preventing infections caused by all nine human papilloma virus (HPV) genotypes for longer than 5 years. [Lancet 2017 Doi:http://dx.doi.org/10.1016/S0140-6736(17)31821-4]

“Seventy-five years ago, cervical cancer was a very common cause of mortality in the US. Looking forward, with widespread vaccination, it is highly likely that cervical cancer will evolve into historical interest only, and screening, like Pap smears, might go away altogether. HPV vaccines are one of the most scrutinized vaccines ever, but multiple studies have demonstrated the vaccine to be safe and well-tolerated,” said primary author Dr Warner Huh, professor and director of the University of Alabama, Birmingham Division of Gynaecologic Oncology and a senior scientist at the UAB Comprehensive Cancer Center, US.

The study is a follow-up of a previous efficacy and safety study of the nine-valent HPV vaccine published in The New England Journal of Medicine. A total of 14,215 women between the ages of 16 and 26 who were healthy, with no history of abnormal cervical cytology, no previous abnormal cervical biopsy results, and ≤4 lifetime sexual partners, participated in the study. The participants were given three intramuscular injections over a duration of 6 months of either the nine-valent or quadrivalent HPV vaccine.

The older four-valent HPV vaccine called Gardasil is effective against four HPV genotypes: HPV 6, 11, 16 and 18. The newer nine-valent HPV vaccine—Gardasil 9—is effective against the same four genotypes and also an additional five: HPV 31, 33, 45, 52 and 58. According to the study findings, the nine-valent HPV vaccine had 97.4 percent efficacy in the prevention of high-grade cervical, vulvar and vaginal disease associated with the additional five HPV genotypes. Both vaccines were equally effective for HPV 6, 11, 16 and 18, and had similar safety profiles.

The primary outcomes measured in the study were the incidence of high-grade cervical disease, vulvar disease and vaginal disease associated with HPV 31, 33, 45, 52 and 58; and non-inferiority of anti-HPV 6, 11, 16 and 18 geometric mean titres.

Human papilloma virus can cause cervical, vulvar, vaginal and anal cancers. Globally, cervical cancer is the fourth most common cancer in women and in low-income countries, HPV is the cause of nearly all cervical cancers. [Arch Pharm Res 2017. Doi:10.1007/s12272-017-0952-8. Epub ahead of print]

There are three HPV vaccines available in the market, namely Cervarix (bivalent), Gardasil and Gardasil 9. Despite the availability of vaccines, vaccination rates are suboptimal. According to studies, the reasons include a lack of knowledge on the disease and vaccine, and not receiving a recommendation from healthcare practitioner. [Glob Health Action 2016;9(1):29336, J Adolesc Health 2017;61(3):288–293] 

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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.