Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.

Night-time blood pressure predicts left atrial enlargement

09 Aug 2018

Higher values and variability of night-time blood pressure are linked with left atrial enlargement, a recent study has found.

A total of 140 patients (mean age 64±10 years; 74 percent male) were eligible for analysis, of whom 59 percent (n=82) had paroxysmal while 41 percent (n=58) had persistent atrial fibrillation (AF). Majority (74 percent) had well-controlled hypertension without the coexistence of left ventricular hypertrophy.

Multiple regression analysis adjusted for age, sex, antihypertensive medication and left ventricular mass index showed that mean night-time systolic (SBP; β, 0.32; p<0.0001) and diastolic (DBP; β, 0.35; p<0.0001) blood pressure, along with their respective variabilities (SBP: β, 0.20; p<0.01; DBP: β, 0.23; p<0.01) were significantly correlated with left atrial volume index.

These remained significant predictors of volume even after additional adjustments for the timing of antihypertensive medication, left ventricular ejection fraction, cardio-ankle vascular index and the type of atrial fibrillation.

In contrast, no such significant influence on left atrial volume was exerted by casual SBP (β, 0.14; p=0.07) and DBP (β, 0.14; p=0.07).

To test its predictive value, researchers divided the participants into four groups according to night-time blood pressure and its variability. Those with the highest night-time BP (≥120/70 mm Hg) and variability (standard deviation≥12.2/7.9 mm Hg) had significantly larger left atrial volume indices than those with lower values (46.6±13.5 vs 35.0±8.8 mL/m2; p<0.0001).

For the present study, a home monitoring device was provided for the measurement of night-time BP, which collected hourly measurements during sleep hours. Left atrial volume was assessed through transthoracic echocardiography.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.