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Nicotine replacement therapy does not adversely affect surgical outcomes among smokers

13 Dec 2019

Nicotine replacement therapy (NRT) may be safely administered in smokers undergoing a major surgical procedure, with a recent study showing that perioperative NRT does not adversely influence postoperative outcomes.

The study included 147,506 active smokers who had undergone a major surgical procedure (Medicare Severity Diagnosis-Related Group expected length of stay of ≥2 days). Of these, 25,651 patients (17.4 percent) were prescribed NRT within 2 days of admission.

Compared with nontreated patients, those who were treated with NRT were younger, less likely to be Black or Hispanic, more likely to have Medicaid or have a diagnosis of alcohol, substance abuse disorder, or chronic obstructive pulmonary disease.

Propensity matched analysis revealed that receipt of NRT within 2 days of admission was not associated with the following outcomes: in-hospital complications (odds ratio [OR], 0.99, 95 percent confidence interval [CI], 0.93–1.05), mortality (OR, 0.84, 95 percent CI, 0.68–1.04), all-cause 30-day readmissions (OR, 1.02, 95 percent CI, 0.97–1.07) and 30-day readmission for wound complications (OR, 0.96, 95 percent CI, 0.86–1.07).

The current large observational study of surgical patients who actively smoked is the first to demonstrate that perioperative NRT is not associated with adverse outcomes following surgery, researchers said.

The findings should temper concerns regarding the potential negative effect of NRT on wound healing and hence strengthen the evidence that NRT should be prescribed routinely in the perioperative period, they added.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.