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Stephen Padilla, 28 Nov 2017
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Nicotinamide riboside supplementation safe but ineffective in obese, insulin-resistant men

03 Sep 2018

Dietary nicotinamide riboside (NR) supplementation in 2,000-mg doses daily over a 12-week period is safe, a recent study has shown. However, it does not improve insulin sensitivity and whole-body glucose metabolism in obese, insulin-resistant men.

NR supplementation failed to improve insulin sensitivity, endogenous glucose production, and glucose disposal and oxidation. NR supplementation also had no effect on resting energy expenditure, lipolysis, oxidation of lipids or body composition.

On the other hand, there were no serious adverse events caused by NR supplementation. Safety blood tests were also normal.

In this investigator-initiated randomized, placebo-controlled, double-blinded and parallel-group designed clinical trial, a total of 40 healthy, sedentary men (age range, 40–70 years) with a body mass index of >30 kg/m2 were randomly assigned to 12 weeks of NR (1,000 mg twice daily) or placebo.

The effects of NR supplementation on insulin sensitivity were determined by a hyperinsulinaemic euglycaemic clamp and substrate metabolism by indirect calorimetry and labeled substrates of tritiated glucose and palmitate.

Whole-body dual-energy X-ray absorptiometry and MRI scans were used to determine body composition and fat mass distribution. Finally, MR spectroscopy was used to obtain measurement of intrahepatic lipid content.

“Animal studies suggest a positive role for NR on insulin sensitivity and hepatic steatosis in models of obesity and type 2 diabetes,” the authors said. “NR, an NAD+ precursor, is a member of the vitamin B-3 family now available as an over-the-counter supplement.”

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Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
Pearl Toh, 20 Apr 2018
The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.
02 Aug 2018
Men and women who regularly eat seafood appear to have higher sexual intercourse frequency (SIF) and fecundity in a large prospective cohort of couples attempting pregnancy, suggests a study.
12 Apr 2018
In the context of low-glycaemic index (GI) dietary patterns, eating pasta does not contribute to adiposity and may even reduce body weight and body mass index (BMI) compared with higher-GI dietary patterns, a recent study has found.