Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

New factors to consider for diagnosis of Cowden syndrome

18 Jul 2017

Cowden syndrome has variable clinical phenotypes and gastrointestinal (GI) manifestations, but a study has recently added new considerations for diagnosis of this syndrome: multiple GI hamartomas, particularly two or more hamartoma types, and any intramucosal lipomas or ganglioneuromas.

Researchers selected Cowden patients (n=19) with GI polyps for medical record and pathologic slide review to further characterize the GI manifestations of the syndrome and improve its diagnosis.

Genetic testing indicated pathogenic PTEN mutations in 12 of the total patients. Pan-colonic (n=11; 58 percent) and pan-GI (n=8; 42 percent) polyp distributions were common. The most common hamartomatous polyps were inflammatory (juvenile) polyps (n=18; 95 percent), along with expansive lymphoid follicle polyps (n=12; 63 percent), ganglioneuromatous polyps (n=10; 53 percent) and intramucosal lipomas (n=5; 26 percent).

A new and highly prevalent (79 percent) feature of Cowden syndrome that emerged was the findings of two or more hamartomatous polyp types per patient. Additional evaluation should be initiated for ganglioneuromatous polyps, which are rare in the general population, and intramucosal lipomas, which may be unique to Cowden syndrome.

Furthermore, colonic adenomas and adenocarcinomas were common. There were 10 (53 percent) and three (16 percent) patients who had single and ≥3 adenomas, respectively. On the other hand, two patients (11 percent) had colonic adenocarcinoma, which supports the emerging association of colorectal cancer with Cowden syndrome.

“These features should warrant consideration of Cowden syndrome,” according to researchers, adding that proper diagnosis is critical for effective cancer surveillance and prevention in such patients.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.