Most Read Articles
16 Aug 2018
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
Roshini Claire Anthony, 15 Aug 2018

Changes in cardiometabolic factors such as body mass index (BMI), glucose levels, and blood pressure (BP) may signify dementia risk up to 14 years pre-diagnosis, with management of these risk factors potentially preventing dementia, according to a French population-based study presented at the Alzheimer’s Association International Conference (AAIC 2018).

09 Oct 2018
An association exists between hypoglycaemia and elevated high-sensitivity cardiac troponin T (hsTnT) levels, a recent study shows. However, such association is probably due to more severe diabetes in patients who developed hypoglycaemia, instead of a direct result of hypoglycaemia.
Roshini Claire Anthony, 5 days ago

The risk of hospitalization due to heart failure was almost halved in patients with secondary mitral regurgitation who underwent transcatheter mitral valve repair plus medical therapy compared with those who underwent medical therapy alone, according to findings of the COAPT* trial.

New data show promise for renal denervation in hypertension

12 Jun 2018

Renal denervation provides meaningful reductions in systolic blood pressure (BP) in hypertensive patients on or off BP-lowering medications, results of the SPYRAL HTN-ON MED and RADIANCE-HTN SOLO trials have shown.

In SPYRAL HTN-ON MED, 467 patients with uncontrolled hypertension despite the use of up to three antihypertensive medications were randomized to undergo renal denervation or a sham control procedure. Results from the first 80 patients showed significantly greater reductions in the renal denervation vs sham control group in office systolic BP (difference, -6.8 mm Hg; p=0.05), 24-hour systolic BP (difference, -7.4 mm Hg; p=0.0051), office diastolic BP (difference, -3.5 mm Hg; p=0.0478) and 24-hour diastolic BP (difference, -4.1 mm Hg, p=0.0292) at 6 months. [Lancet 2018, doi: https://doi.org/10.1016/S0140-6736(18)30951-6]

In RADIANCE-HTN SOLO, 146 patients with hypertension after discontinuation of up to two antihypertensive medications were randomized to undergo renal denervation or a sham procedure. At 2 months, patients in the renal denervation group had greater reductions in daytime ambulatory systolic BP than those in the sham control group (difference, -6.3 mm Hg; p=0.0001). [Lancet 2018, doi: https://doi.org/10.1016/S0140-6736(18)31082-1]

The two trials enrolled different patient populations. In SPYRAL HTN-ON MED, eligible patients had an office systolic BP of 150–180 mm Hg and a diastolic BP of 90 mm Hg, a 24-hour ambulatory systolic BP of 140–170 mm Hg at second screening, and were on 1–3 antihypertensive medications at stable doses for at least 6 weeks. In contrast, RADIANCE-HTN SOLO enrolled patients with ambulatory BP of 135/85 mm Hg and <170/105 mm Hg after a 4-week discontinuation of 2 antihypertensive medications.

No major adverse events were reported for either procedure in both trials. In SPYRAL HTN-ON MED, adherence to antihypertensive medications was incomplete, at about 60 percent, and varied for individual patients throughout the trial.

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Most Read Articles
16 Aug 2018
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
Roshini Claire Anthony, 15 Aug 2018

Changes in cardiometabolic factors such as body mass index (BMI), glucose levels, and blood pressure (BP) may signify dementia risk up to 14 years pre-diagnosis, with management of these risk factors potentially preventing dementia, according to a French population-based study presented at the Alzheimer’s Association International Conference (AAIC 2018).

09 Oct 2018
An association exists between hypoglycaemia and elevated high-sensitivity cardiac troponin T (hsTnT) levels, a recent study shows. However, such association is probably due to more severe diabetes in patients who developed hypoglycaemia, instead of a direct result of hypoglycaemia.
Roshini Claire Anthony, 5 days ago

The risk of hospitalization due to heart failure was almost halved in patients with secondary mitral regurgitation who underwent transcatheter mitral valve repair plus medical therapy compared with those who underwent medical therapy alone, according to findings of the COAPT* trial.