Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
Jairia Dela Cruz, 29 Jan 2020
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.

New biomarker may predict dementia early

Saras Ramiya
20 Jul 2020

Researchers from the Flinders University in Australia and University of Aberdeen in the UK have found that a biomarker associated with atherosclerosis and cardiovascular disease, asymmetric dimethylarginine (ADMA), is also associated with declining cognitive performance in the elderly.

The universities conducted a new study in participants of the 1936 Aberdeen Birth Cohort  which investigated the association between ADMA levels in 2000 and temporal changes in cognition in 2004. [Int J Geriatr Psychiatry. 2020 May 25. doi: 10.1002/gps.5355]

In the study comprising 93 participants aged 63 years, 0.06 µmol/L increase in ADMA levels was linked to an average decline in cognitive performance (Raven’s progressive matrices of 1.26 points, 95 percent confidence interval 0.14–2.26) after 4 years.

“Therefore, the results of this study suggest that ADMA, an easily measurable marker of atherosclerosis and cardiovascular risk, could be an early indicator of cognitive decline in old age—and possibly dementia,” said Professor Arduino Mangoni, Head of Clinical Pharmacology at Flinders University.

According to Deborah Malden, Ph.D, a researcher from the University of Oxford, the results of the new study should be approached with caution and need further extensive investigations.

“We would know much more after repeating this study in a large-scale cohort, potentially tens of thousands of individuals, and perhaps a genetic MR (Mendelian randomization) study,” said Malden.  

If large-scale testing confirms the initial study findings, researchers hope it will lead to population-wide dementia risk stratification and perhaps future development of therapeutic strategies to reduce ADMA levels and/or slow the progression of cognitive decline in old age.

Although not part of current clinical practice, there are genetic animal studies and drug interventions in animals and humans that significantly reduce ADMA levels.

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Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
Jairia Dela Cruz, 29 Jan 2020
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.