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Neutrophil-to-lymphocyte ratio predicts myocardial injury after noncardiac surgery

12 May 2018
The more painful the surgery, the more likely addiction is, according to a report by the research firm QuintilesIMS Institute for Healthcare Informatics

The neutrophil-to-lymphocyte ratio (NLR) appears to be a simple and easy method for predicting the development of myocardial injury after noncardiac surgery (MINS), a recent study has shown.

Peak high-sensitivity cardiac troponin T (hs-cTnT; 126.6 vs 7.5; p<0.000), mean neutrophil count (6,498±819 vs 5,978±998 mm-3; p=0.007) and median C-reactive protein (CRP) levels (3.0 vs 2.5; p=0.02) were significantly higher in those with vs without MINS, as was mean NLR (3.79±0.7 vs 2.69±0.6; p<0.0001).

In contrast, lymphocyte count was significantly lower in patients with MINS (1,857±331 vs 2,038±391 mm-3; p=0.016).

Moreover, multivariate logistic regression analysis showed that the variables independently and significantly associated with MINS were age (odds ratio [OR], 1.081; 95 percent CI, 1.004–1.165; p=0.039), CRP concentration (OR, 1.552; 1.009–2.386; p=0.045), lymphocyte count (OR, 1.002; 1.001–1.004; p=0.040) and NLR (OR, 11.690; 4.619–29.585; p<0.000).

At a cutoff value of 3.3, receiver operating characteristic analysis showed that NLR could predict MINS with an 80-percent sensitivity and 84-percent specificity (area under the curve, 0.85; 0.78–0.93).

The findings of the present study support the use of preoperative NLR as an easy, inexpensive and noninvasive marker for the detection of patients at high risk of cardiac complications after noncardiac surgery.

Using blood samples collected from 255 patients who underwent noncardiac surgery after a 12-hour fast, researchers measured CRP, glucose and triglyceride levels, along with blood cell counts. Electrocardiography and hs-cTnT measurements were performed immediately after surgery and at 1 and 3 days after surgery.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Pank Jit Sin, 07 Jun 2018
A reduction as small as 2 mm Hg can lower cardiovascular risks among patients with cardiovascular disease (CVD), says an expert.
01 Mar 2016
Teaching healthcare providers to execute a chest compression (CC) of 6-7 cm depth may enhance quality CC depth in patients on a mattress during cardiopulmonary resuscitation (CPR) in the hospital, based on a prospective, randomised, controlled study.
06 Jun 2018
Increased concentrations of omega-3 fatty acid (n-3 FA) appear to contribute to a clinically relevant reduction in blood pressure (BP) levels among normotensive young and healthy individuals, as shown by the results of a recent cross-sectional study.