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22 Jul 2020
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Neurophysiological factors linked to GI symptoms in IBS

30 Jun 2020

Neurophysiological factors appear to play a role in gastrointestinal (GI) symptoms in patients with irritable bowel syndrome (IBS), a recent study has found.

The study included 281 IBS patients (median age, 36 years; 74 percent female), who showed normal median anxiety and depression levels. Among the neurophysiology factors were psychological distress, colonic and small intestinal motility, and small intestinal secretions, among others. Patients were not categorized according to different IBS subgroups for analyses.

Psychological distress, as a neurophysiology manifestation of the central nervous system, was significantly correlated with GI symptom severity, as were variables associated with rectal sensitivity (p<0.05). No such effect was found for small intestinal motility and secretion, rectal tone response, or autonomic nervous system function.

A total of 193 participants were able to complete the Gastrointestinal Symptom Rating Scale, IBS version (GSRS-IBS) and were eligible for subsequent multivariate analysis. In general, GI symptoms more strongly correlated with specific combinations of neurophysiological factors than with the total neurophysiological score.

“The benefit of this approach relative to assessing the neurophysiological factors individually was modest, further highlighting the complexity of symptom generation in IBS,” researchers said.

Notably, two neurophysiological factors were present in every reduced neurophysiology score: central nervous system function, manifested as psychological distress, and visceral sensitivity patterns. This suggested that these factors were the most crucial of GI symptoms in this cohort.

“Further studies with an expanded range of neurophysiological variables of importance for symptom generation in IBS can be considered,” researchers said.

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Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
Elvira Manzano, 28 Jul 2020
The efficacy and cardiovascular (CV) safety of the SGLT2* inhibitor empagliflozin vs DPP-4** inhibitors and GLP-1*** receptor agonists in real-world patients were demonstrated in two interim analyses of the EMPRISE+ study presented at ADA 2020.
3 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 28 Jul 2020
Higher levels of plasma vitamin C, total and individual carotenoid biomarkers, and their composite biomarker score appear to reduce the incidence of type 2 diabetes (T2D), according to the results of a prospective case-cohort study in eight European countries.