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Neurogenic bladder amplifies complication risk after implantable penile prosthesis placement

15 Sep 2020

Men with neurogenic bladder (NGB) are at higher risk of complications after placement of implantable penile prostheses (IPPs), a recent study has shown.

Researchers retrieved the records of 37 men with NGB (median age, 48 years) who underwent IPP placement. Study endpoints included surgical outcomes, complications, and the use of medications such as anticholinergic or beta-3 agonists. A parallel group of 267 men without NGB (median age, 62 years), but who received IPPs for erectile dysfunction, was also included.

In both groups, most of the participants underwent IPP placement for the first time under study enrollment. The most common causes for NGB in the study cohort were spinal cord injuries (46.0 percent), spine surgery (23.3 percent), and multiple sclerosis (10.8 percent).

Complications occurred significantly more frequently in NGB participants than in controls (24.3 percent vs 7.5 percent; p=0.001). Specific complications, such as mechanical problems, erosion, and infection, remained more prevalent in the NGB group.

Multivariate logistic regression analysis confirmed that NGB was a strong and significant risk factor for the development of IPP complications (odds ratio [OR], 3.47, 95 percent confidence interval [CI], 1.13–10.71; p=0.03).

Chronic obstructive pulmonary disease also emerged as a significant risk factor (OR, 3.88, 95 percent CI, 1.39–10.79; p=0.009), while those who underwent IPP placement for the first time were at a reduced risk of complications (OR, 0.25, 95 percent CI, 0.09–0.71; p=0.01).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.