Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Neurodegenerative diseases may predispose patients to epilepsy

5 days ago

Older patients with neurodegenerative diseases frequently develop epilepsy, especially those with a history of depression, traumatic brain injury (TBI), or stroke, a study has found.

The analysis included 178,593 older adults with incident Alzheimer’s disease (AD) and 104,157 with incident Parkinson’s disease (PD) among 34,054,293 Medicare beneficiaries with complete data in 2009. Compared with controls without the neurodegenerative diseases, patients with AD or PD were more likely to be female (65.3 percent and 50.7 percent, respectively) and older (median age, 84 and 80 years, respectively). 

Individuals with AD or PD were more often diagnosed with every chronic condition investigated except endometrial cancer and female breast cancer.

Over the 5-year follow-up period, 126,362 AD patients and 63,319 PD patients died. Epilepsy occurred in 4.45 percent of patients in the AD cohort and in 4.81 percent of those in the PD cohort, the incidence being twice as high as in the control group. Minority race/ethnicity was associated with increased risk of incident epilepsy.

Among individuals with AD and PD, the risk of incident epilepsy increased significantly in the presence of a previous stroke (adjusted hazard ratios [aHRs], 2.18 and 2.11, respectively) and depression (aHRs, 1.23 and 1.45, respectively).

In PD only, a history of TBI (aHR, 1.35), hip fracture (AHR, 1.35), and diabetes (aHR, 1.11) also contributed to a heightened risk of epilepsy.

Additional investigation is needed to shed light on the different mechanisms of epileptogenesis in AD and PD.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).