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3 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Jairia Dela Cruz, 3 days ago
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Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Neurodegenerative diseases may predispose patients to epilepsy

20 Nov 2020

Older patients with neurodegenerative diseases frequently develop epilepsy, especially those with a history of depression, traumatic brain injury (TBI), or stroke, a study has found.

The analysis included 178,593 older adults with incident Alzheimer’s disease (AD) and 104,157 with incident Parkinson’s disease (PD) among 34,054,293 Medicare beneficiaries with complete data in 2009. Compared with controls without the neurodegenerative diseases, patients with AD or PD were more likely to be female (65.3 percent and 50.7 percent, respectively) and older (median age, 84 and 80 years, respectively). 

Individuals with AD or PD were more often diagnosed with every chronic condition investigated except endometrial cancer and female breast cancer.

Over the 5-year follow-up period, 126,362 AD patients and 63,319 PD patients died. Epilepsy occurred in 4.45 percent of patients in the AD cohort and in 4.81 percent of those in the PD cohort, the incidence being twice as high as in the control group. Minority race/ethnicity was associated with increased risk of incident epilepsy.

Among individuals with AD and PD, the risk of incident epilepsy increased significantly in the presence of a previous stroke (adjusted hazard ratios [aHRs], 2.18 and 2.11, respectively) and depression (aHRs, 1.23 and 1.45, respectively).

In PD only, a history of TBI (aHR, 1.35), hip fracture (AHR, 1.35), and diabetes (aHR, 1.11) also contributed to a heightened risk of epilepsy.

Additional investigation is needed to shed light on the different mechanisms of epileptogenesis in AD and PD.

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Most Read Articles
3 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
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The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Jairia Dela Cruz, 3 days ago
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.