Most Read Articles
01 Nov 2019
Women with hypertensive disorders of pregnancy, especially pre-eclampsia, are at heightened risk of developing cardiovascular disorder and chronic hypertension, with the risk becoming apparent soon after pregnancy, a study has found.
Roshini Claire Anthony, 29 May 2019

Gestational diabetes and abnormal glucose levels in pregnancy, as determined with an oral glucose challenge test (OGCT) at 24–28 weeks gestation, could signal a future risk of cardiovascular disease (CVD)*, according to a recent study.

07 Jul 2019
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
Pank Jit Sin, 16 Oct 2019
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers. 

Neurodegeneration speeds up in presence of vascular risk factors

05 Oct 2019

Vascular risk factors may accelerate neurodegeneration but not the accumulation of amyloid deposits, a recent study has found.

A total of 433 cognitively normal adults (mean age, 68.3±8.5 years; 53 percent female) were enrolled in the study. All participants underwent clinical assessment with the Mini-Mental State Examination (MMSE), as well as a psychometric battery consisting of different cognitive tests. The vascular risk factors included were hypertension, hypercholesterolaemia, diabetes mellitus, depression, smoking and alcohol use habits, and transient ischaemic attacks, among others.

Over a mean clinical follow-up of 5.2±2.7 years, hypercholesterolaemia emerged as the most common vascular risk factor (65 percent). This was followed by hypertension (58 percent) and depression (36 percent). Majority of the participants (72 percent; n=312) had more than one risk factor.

Vascular risk factors appeared to be important in those with preclinical Alzheimer’s disease. Particularly, in participants who were positive for amyloid and tau at baseline, the Framingham Risk Score (FRS) correlated inversely with baseline MMSE scores (p=0.023) and longitudinal decline (p=0.031). Depression, on the other hand, was associated with higher baseline scores (p=0.045).

In the same subgroup of participants, obesity was likewise inversely correlated with baseline p-tau concentrations (p=0.021). In comparison, hypertension as associated with a greater rate of accumulation of t-tau (p=0.002) and p-tau (p<0.001), and a higher FRS was linked to a longitudinal increase in t-tau (p=0.042).

In the overall sample and in any of the subgroups, none of the vascular risk factors assessed yielded significant effects on amyloid accumulation.

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Most Read Articles
01 Nov 2019
Women with hypertensive disorders of pregnancy, especially pre-eclampsia, are at heightened risk of developing cardiovascular disorder and chronic hypertension, with the risk becoming apparent soon after pregnancy, a study has found.
Roshini Claire Anthony, 29 May 2019

Gestational diabetes and abnormal glucose levels in pregnancy, as determined with an oral glucose challenge test (OGCT) at 24–28 weeks gestation, could signal a future risk of cardiovascular disease (CVD)*, according to a recent study.

07 Jul 2019
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
Pank Jit Sin, 16 Oct 2019
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers.