Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

Neurodegeneration speeds up in presence of vascular risk factors

05 Oct 2019

Vascular risk factors may accelerate neurodegeneration but not the accumulation of amyloid deposits, a recent study has found.

A total of 433 cognitively normal adults (mean age, 68.3±8.5 years; 53 percent female) were enrolled in the study. All participants underwent clinical assessment with the Mini-Mental State Examination (MMSE), as well as a psychometric battery consisting of different cognitive tests. The vascular risk factors included were hypertension, hypercholesterolaemia, diabetes mellitus, depression, smoking and alcohol use habits, and transient ischaemic attacks, among others.

Over a mean clinical follow-up of 5.2±2.7 years, hypercholesterolaemia emerged as the most common vascular risk factor (65 percent). This was followed by hypertension (58 percent) and depression (36 percent). Majority of the participants (72 percent; n=312) had more than one risk factor.

Vascular risk factors appeared to be important in those with preclinical Alzheimer’s disease. Particularly, in participants who were positive for amyloid and tau at baseline, the Framingham Risk Score (FRS) correlated inversely with baseline MMSE scores (p=0.023) and longitudinal decline (p=0.031). Depression, on the other hand, was associated with higher baseline scores (p=0.045).

In the same subgroup of participants, obesity was likewise inversely correlated with baseline p-tau concentrations (p=0.021). In comparison, hypertension as associated with a greater rate of accumulation of t-tau (p=0.002) and p-tau (p<0.001), and a higher FRS was linked to a longitudinal increase in t-tau (p=0.042).

In the overall sample and in any of the subgroups, none of the vascular risk factors assessed yielded significant effects on amyloid accumulation.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.