Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Neoadjuvant chemoradiation tied to better disease control of high-risk soft tissue sarcoma

5 days ago
The latest Linear Accelerator (LINAC) technology is capable of zeroing in on a tumor and minimizing damage to surrounding cells.

Management of high-risk soft tissue sarcoma (STS) with neoadjuvant chemoradiation (NA-CRT) shows favourable disease control, reports a new study.

On the other hand, a delay in surgical resection leads to inferior local control (LC). Such finding warrants further research in a larger cohort, according to the investigators.

In this study, the investigators obtained data on delay to surgical resection, resection margin status, extent of necrosis, tumour cell viability, presence of hyalinization, positron emission tomography (PET)/computed tomography data, and treatment toxicities. They estimated 5-year overall survival, disease-free survival, distant metastasis-free survival, and LC using the Kaplan-Meier survival analysis.

Finally, the log-rank test was used to assess clinicopathologic features and PET/computed tomography avidity changes for their potential predictive impact.

Thirty-seven consecutive cases of localized high-risk STS were identified from 2011 to 2018, of whom 29 underwent ifosfamide-based NA-CRT at a median dose of 50 Gy before en bloc resection. Estimated 5-year overall survival, disease-free survival, distant metastasis-free survival, and LC at a median follow-up of 40.3 months were 86.1 percent, 70.2 percent, 75.2 percent, and 86.7 percent, respectively.

A median reduction of 54.7 percent was observed in tumour PET avidity following NA-CRT. In 13.8 percent of patients, a median tumour necrosis of 60.0 percent with no viable tumour cells was detected once resected.

All patients had negative post-treatment resection margins, with 27.6 percent having a margin of ≤1 mm. Nearly one in five patients (20.7 percent) had delays of over 6 weeks following the end of radiation treatment to surgical resection; such delay indicated inferior LC (92.8 percent vs 68.6 percent; p=0.025).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.