Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
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Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

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Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Necitumumab added to first-line chemo improves overall survival in advanced NSCLC

02 Sep 2020

Adding necitumumab to first-line chemotherapy in patients with stage IV nonsmall-cell lung cancer (NSCLC) leads to a statistically significant improvement in overall survival, but not progression-free survival and objective response rate, according to a recent meta-analysis.

The investigators conducted a comprehensive literature search according to prespecified inclusion and exclusion criteria, and extracted data on overall survival, progression-free survival, objective response rate, and adverse events. A meta-analysis was then carried out to obtain pooled hazard ratios (HRs) and corresponding 95 percent confidence intervals (CIs) for time-to-event data and pooled odds ratio (ORs) with 95 percent CI for dichotomous outcomes.

Four randomized controlled trials with 2,074 patients were included in the meta-analysis. Pooled results showed significant improvement in overall survival (HR, 0.87, 95 percent CI, 0.79–0.95; p=0.004) when necitumumab was added to chemotherapy in advanced NSCLC patients. However, there was no statistically significant improvement seen in progression-free survival (HR, 0.83, 95 percent CI, 0.69–1.01; p=0.06) and objective response rate (OR, 1.46, 95 percent CI, 0.90–2.38; p=0.13).

Subgroup analysis revealed no benefit in overall survival and objective response rate in patients with nonsquamous NSCLC. Furthermore, those with advanced NSCLC treated with necitumumab were at increased risk of developing a skin rash (OR, 14.50, 95 percent CI, 3.16–66.43; p=0.0006) and hypomagnesaemia (OR, 2.77, 95 percent CI, 2.23–3.45; p<0.00001); the OR for any grade ≥3 adverse event was 1.55 (95 percent CI, 1.28–1.87; p<0.00001).

“Almost half of patients with NSCLC are diagnosed at an advanced stage,” the investigators noted.

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Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.