Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, Yesterday

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 12 Sep 2019
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Natamycin plus ISV injection confers no benefit in filamentous fungal ulcers

05 Aug 2019

The addition of intrastromal voriconazole (ISV) to topical natamycin does not appear to provide any benefit in the primary treatment of moderate-to-severe filamentous fungal ulcers, a recent study in India has found.

“Studies consistently suggest that voriconazole has a limited role in the treatment of filamentous fungal ulcers,” according to the investigators.

This outcome-masked, randomized controlled clinical trial included 151 patients with moderate vision loss resulting from a smear-positive fungal ulcer. Study eyes were randomly assigned to either topical natamycin plus ISV injection or topical natamycin alone.

Microbiological cure on 3-day repeat culture analysis was the primary outcome, while secondary outcomes included microbiological cure on 7-day repeat culture analysis, 3-week and 3-month best spectacle-corrected visual acuity, infiltrate or scar size or both, perforation rate, therapeutic penetrating keratoplasty (TPK), and other adverse events.

Of the patients, 70 were enrolled at the Aravind Eye Hospital in Pondicherry, India. Baseline cultures grew Fusarium in 19 patients (27 percent), Aspergillus in 17 (24 percent) and other filamentous fungi in 19 (27 percent). Thirteen patients (19 percent) had negative results.

After controlling for baseline culture status, ISV injection was associated with a 1.82-fold risk of 3-day culture positivity (95 percent CI, 0.65–5.23; p=0.26) and a 1.98-fold risk of positive 7-day culture results (0.69–5.91; p=0.20).

Patients in the ISV injection arm had 0.5 logMAR lines (approximately 0.5 Snellen lines, –2.6 to 3.6 lines; p=0.75) of decreased visual acuity and 0.55 mm (–0.13 to 1.25; p=0.11) worse infiltrate or scar size or both at 3 months after controlling for baseline values.

Furthermore, ISV injection was associated with a 2.85-fold (0.76–10.75; p=0.12) increased risk of perforation after controlling for baseline infiltrate depth. However, there was no difference in the rate of TPK (hazard ratio, 0.95, 0.44–2.04; p=0.90).

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, Yesterday

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 12 Sep 2019
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.