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Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

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Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
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Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
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Natamycin plus ISV injection confers no benefit in filamentous fungal ulcers

05 Aug 2019

The addition of intrastromal voriconazole (ISV) to topical natamycin does not appear to provide any benefit in the primary treatment of moderate-to-severe filamentous fungal ulcers, a recent study in India has found.

“Studies consistently suggest that voriconazole has a limited role in the treatment of filamentous fungal ulcers,” according to the investigators.

This outcome-masked, randomized controlled clinical trial included 151 patients with moderate vision loss resulting from a smear-positive fungal ulcer. Study eyes were randomly assigned to either topical natamycin plus ISV injection or topical natamycin alone.

Microbiological cure on 3-day repeat culture analysis was the primary outcome, while secondary outcomes included microbiological cure on 7-day repeat culture analysis, 3-week and 3-month best spectacle-corrected visual acuity, infiltrate or scar size or both, perforation rate, therapeutic penetrating keratoplasty (TPK), and other adverse events.

Of the patients, 70 were enrolled at the Aravind Eye Hospital in Pondicherry, India. Baseline cultures grew Fusarium in 19 patients (27 percent), Aspergillus in 17 (24 percent) and other filamentous fungi in 19 (27 percent). Thirteen patients (19 percent) had negative results.

After controlling for baseline culture status, ISV injection was associated with a 1.82-fold risk of 3-day culture positivity (95 percent CI, 0.65–5.23; p=0.26) and a 1.98-fold risk of positive 7-day culture results (0.69–5.91; p=0.20).

Patients in the ISV injection arm had 0.5 logMAR lines (approximately 0.5 Snellen lines, –2.6 to 3.6 lines; p=0.75) of decreased visual acuity and 0.55 mm (–0.13 to 1.25; p=0.11) worse infiltrate or scar size or both at 3 months after controlling for baseline values.

Furthermore, ISV injection was associated with a 2.85-fold (0.76–10.75; p=0.12) increased risk of perforation after controlling for baseline infiltrate depth. However, there was no difference in the rate of TPK (hazard ratio, 0.95, 0.44–2.04; p=0.90).

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Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.