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Nasal gel ups testosterone in men with functional hypogonadism

04 Sep 2020

Use of the short-acting 4.5% nasal testosterone gel Natesto leads to increased testosterone levels while maintaining semen parameters in men, indicating its potential as a safe and effective treatment for patients with functional hypogonadism, results of a trial have shown.

This single-centre, open-label, single-arm trial was conducted between November 2017 and September 2019 at the University of Miami, US. The study included men aged 18–55 years who were diagnosed with symptomatic hypogonadism (total testosterone <300 ng/dl on two occasions). Excluded were those with azoospermia, vasectomy, or total sperm count <5 million.

Sixty men met the eligibility criteria, of whom 44 and 33 patients were assessed for testosterone at 3 and 6 months, respectively. Thirty-one patients (90.9 percent) achieved a normal testosterone level (>300 ng/dl) at 6 months.

Of the patients, 81.8 percent and 72.7 percent maintained follicle stimulating hormone and luteinizing hormone levels, respectively, within the normal range at 6 months. Moreover, 88.4 percent and 93.9 percent of men maintained total motile sperm count >5 million over the treatment period at 3 months and 6 months, respectively.

Statistically significant improvements were observed on International Index of Erectile Function sexual desire and overall satisfaction domains at 6 months.

“Long-term studies beyond 6 months are needed before we can safely prescribe nasal testosterone gel for men interested in fertility,” the investigators said.

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Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 18 hours ago
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Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
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