Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Nagahama Study: Nocturia predicts mortality

26 Oct 2020

Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

The investigators examined the association between nocturia and mortality using data obtained from the Nagahama Cohort Project, a longitudinal, general population cohort study. They measured nocturia using the International Prostate Symptom Score and obtained mortality data from the Basic Resident Register in Nagahama City. Cox proportional hazard models and time-varying covariates at baseline and 5-year follow-up were used to analyse the association between nocturia and death.

A total of 9,762 participants (median age, 56.8 years; 32.8 percent male) were included in the analysis. The prevalence rates of nocturnal voiding were 44.3 percent at 0 times, 39.1 percent at 1 time, 11.7 percent at 2 times, and 4.9 percent at 3 times. Of the participants, 263 died during the study period. Follow-up assessment was carried out 3,224 days after baseline.

Multivariable Cox proportional hazard regression analysis revealed a dose-dependent increase in mortality with nocturnal voiding frequency (hazard ratio [HR] for 1 time, 1.46, 95 percent confidence interval [CI], 1.02–2.09; HR for 2 times, 1.85, 95 percent CI, 1.23–2.77; HR for 3 times, 2.06, 95 percent CI, 1.28–3.32) in comparison with 0 times (ptrend=0.00084). Of note, the significant association persisted in the time-varying Cox proportional hazard regression (ptrend=0.0017).

Editor's Recommendations
Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).