Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

NAFLD linked to coronary artery calcification, carotid IMT thickness

07 Aug 2019

Nonalcoholic fatty liver disease (NAFLD) is linked to coronary artery calcification and carotid intima-media thickness (IMT) in people without a history of cardiovascular disease, a recent study has shown.

Accessing the Multiethnic Study of Atherosclerosis (MESA) cohort, researchers enrolled 4,123 participants (mean age, 63±10 years; 55 percent female) who had adequate noncontrast cardiac computed tomography images available for analysis. MESA data were used for liver fat measurements. Those with known cirrhosis and a history of heavy alcohol, oral corticosteroid or amiodarone use were excluded.

Of the participants, only 729 had NAFLD while the other 3,394 did not. Those with the condition tended to be younger (mean, 61±10 vs 63±11 years; p=0.001) but have higher body mass index (31±5 vs 28±5 kg/m2; p<0.001) and waist circumference (105±13 vs 97±14 cm; p<0.001).

Artery stiffness, indicated by a lower distensibility coefficient (2.4±0.9 vs 2.48±1.1 ×10–3 mmHg–1; p<0.001) and Young’s elastic modulus (1,299±618 vs 1,310±580 mmHg; p=0.035), was also significantly higher in participants with NAFLD. The same was true for the prevalence of coronary artery calcification >0 (53 percent vs 49 percent; p=0.071), though of only borderline significance.

Carotid IMT was likewise significantly elevated in participants with NAFLD (0.88±0.18 vs 0.87±0.2 mm; p=0.003).

Logistic regression analysis further confirmed that internal carotid IMT >1 mm (odds ratio [OR], 1.22, 95 percent CI, 1.01–1.47; p<0.05) and coronary artery calcification >0 (OR, 1.41, 1.18–1.75; p<0.005) were both significantly associated with the likelihood of having NAFLD.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.