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Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
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Pearl Toh, 18 hours ago
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NAFLD linked to coronary artery calcification, carotid IMT thickness

07 Aug 2019

Nonalcoholic fatty liver disease (NAFLD) is linked to coronary artery calcification and carotid intima-media thickness (IMT) in people without a history of cardiovascular disease, a recent study has shown.

Accessing the Multiethnic Study of Atherosclerosis (MESA) cohort, researchers enrolled 4,123 participants (mean age, 63±10 years; 55 percent female) who had adequate noncontrast cardiac computed tomography images available for analysis. MESA data were used for liver fat measurements. Those with known cirrhosis and a history of heavy alcohol, oral corticosteroid or amiodarone use were excluded.

Of the participants, only 729 had NAFLD while the other 3,394 did not. Those with the condition tended to be younger (mean, 61±10 vs 63±11 years; p=0.001) but have higher body mass index (31±5 vs 28±5 kg/m2; p<0.001) and waist circumference (105±13 vs 97±14 cm; p<0.001).

Artery stiffness, indicated by a lower distensibility coefficient (2.4±0.9 vs 2.48±1.1 ×10–3 mmHg–1; p<0.001) and Young’s elastic modulus (1,299±618 vs 1,310±580 mmHg; p=0.035), was also significantly higher in participants with NAFLD. The same was true for the prevalence of coronary artery calcification >0 (53 percent vs 49 percent; p=0.071), though of only borderline significance.

Carotid IMT was likewise significantly elevated in participants with NAFLD (0.88±0.18 vs 0.87±0.2 mm; p=0.003).

Logistic regression analysis further confirmed that internal carotid IMT >1 mm (odds ratio [OR], 1.22, 95 percent CI, 1.01–1.47; p<0.05) and coronary artery calcification >0 (OR, 1.41, 1.18–1.75; p<0.005) were both significantly associated with the likelihood of having NAFLD.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
11 Sep 2019
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Pearl Toh, 18 hours ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.