Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

5 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

NAFLD linked to coronary artery calcification, carotid IMT thickness

07 Aug 2019

Nonalcoholic fatty liver disease (NAFLD) is linked to coronary artery calcification and carotid intima-media thickness (IMT) in people without a history of cardiovascular disease, a recent study has shown.

Accessing the Multiethnic Study of Atherosclerosis (MESA) cohort, researchers enrolled 4,123 participants (mean age, 63±10 years; 55 percent female) who had adequate noncontrast cardiac computed tomography images available for analysis. MESA data were used for liver fat measurements. Those with known cirrhosis and a history of heavy alcohol, oral corticosteroid or amiodarone use were excluded.

Of the participants, only 729 had NAFLD while the other 3,394 did not. Those with the condition tended to be younger (mean, 61±10 vs 63±11 years; p=0.001) but have higher body mass index (31±5 vs 28±5 kg/m2; p<0.001) and waist circumference (105±13 vs 97±14 cm; p<0.001).

Artery stiffness, indicated by a lower distensibility coefficient (2.4±0.9 vs 2.48±1.1 ×10–3 mmHg–1; p<0.001) and Young’s elastic modulus (1,299±618 vs 1,310±580 mmHg; p=0.035), was also significantly higher in participants with NAFLD. The same was true for the prevalence of coronary artery calcification >0 (53 percent vs 49 percent; p=0.071), though of only borderline significance.

Carotid IMT was likewise significantly elevated in participants with NAFLD (0.88±0.18 vs 0.87±0.2 mm; p=0.003).

Logistic regression analysis further confirmed that internal carotid IMT >1 mm (odds ratio [OR], 1.22, 95 percent CI, 1.01–1.47; p<0.05) and coronary artery calcification >0 (OR, 1.41, 1.18–1.75; p<0.005) were both significantly associated with the likelihood of having NAFLD.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

5 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.