Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

NAFLD, sarcopoenia up risk of atherosclerotic CVD

11 Apr 2020

Sarcopoenia and nonalcoholic fatty liver disease (NAFLD) independently correlate with a higher risk of atherosclerotic cardiovascular disease (ASCVD), reveals a recent study.

Moreover, NAFLD with significant liver fibrosis and sarcopoenia are also significantly associated with an increased ASCVD risk in patients with NAFLD.

The authors analysed data of 7,191 individuals from the 2008–2011 Korean National Health and Nutrition Examination Surveys database. Dual-energy x-ray absorptiometry was used to calculate the sarcopoenia index.

Sarcopoenia was defined as the lowest quintile sarcopoenia index value (cutoff: 0.882 for men and 0.582 for women), while NAFLD was defined as a comprehensive NAFLD score ≥40. The fibrosis-4 (FIB-4) index was used to evaluate liver fibrosis.

Finally, the authors assessed the risk of ASCVD by using guidelines set by the American College of Cardiology/American Heart Association. High probability of ASCVD was defined as ASCVD risk >10 percent.

NAFLD prevalence stood at 31.2 percent (n=2,241), while that of sarcopoenia was 19.5 percent (n=1,400). The quartile-stratified ASCVD risk scores positively correlated with NAFLD and sarcopoenia (ptrend<0.001 for all).

The risk for high probability of ASCVD was higher (odds ratio [OR], 1.83; p=0.014) among participants with both NAFLD and sarcopoenia than controls without NAFLD and sarcopoenia.

In addition, FIB-4–defined significant liver fibrosis and sarcopoenia increased the risk for high probability of ASCVD (OR, 3.56; p<0.001) in patients with NAFLD compared with controls without FIB-4–defined significant liver fibrosis or sarcopoenia.

“NAFLD and sarcopenia have a close association with an increased risk of ASCVD,” the authors noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.