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The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
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Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

N-acetylcysteine holds little value in COVID-19 treatment

31 Oct 2020

In patients with COVID-19, use of N-acetylcysteine (NAC) at high doses does not seem to prevent respiratory failure among those patients with severe disease, as shown in a study.

Inactivation of angiotensin-converting enzyme 2 by SARS-CoV-2 might lead to a local increase in angiotensin 2 expression, inducing a redox imbalance in alveolar epithelium cells and promoting apoptosis, increased inflammation and, in turn, impaired gas exchange. As such, treatment with NAC was assumed to help restore the redox homeostasis and suppress unfavorable progression in COVID-19 patients.

In the study, 135 patients (average age, 58 years; 30.37 percent male) suspected of or with confirmed severe COVID-19 were randomized to receive either NAC 21 g (approximately 300 mg/kg; n=67) or dextrose 5% (placebo; n=68) for 20 hours. All patients had an oxyhaemoglobin saturation of <94 percent or respiratory rate higher than 24 breaths/minute.

The two groups had very similar baseline characteristics, including age, sex, comorbidities, medicines taken, disease severity, as well as laboratory tests and chest CT scan findings. Following treatment, there was still no significant difference in the primary endpoint of the number of patients who were subjected to endotracheal intubation and mechanical ventilation (20.6 percent with NAC vs 23.9 percent with placebo).

Likewise, there were no significant differences noted in the secondary endpoints of time of mechanical ventilation, admission to intensive care unit (ICU), time in ICU, and mortality.

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Most Read Articles
3 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
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Jairia Dela Cruz, 3 days ago
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.