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N-3 long-chain polyunsaturated fatty acid supplements boost cognition in elderly

19 Apr 2020

Elderly adults with mild cognitive impairment (MCI) may derive benefits from N-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), reports a recent meta-analysis.

Researchers performed a comprehensive literature search of the Google Scholar, Embase and PubMed databases. They retrieved seven randomized controlled trials, corresponding to 213 patients on active intervention and 221 on placebo. Studies that combined fatty acids with other interventions, and those that were of other methodological designs, were ineligible.

Across the included studies, the duration of the intervention ranged from 3–24 months. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) doses ranged from 180–1,300 and 40–720 mg, respectively. Outcome was cognitive function, as measured by the mini-mental state examination (MMSE).

Pooled analysis found that n-3 LC-PUFAs had a significant and positive correlation with MMSE cognitive function (weighted mean difference [WMD], 0.85, 95 percent confidence interval, 0.04–1.67; p=0.04). There was slight heterogeneity of evidence, which was of borderline significance (p=0.05).

Sensitivity analysis, carried out by removing studies one at a time, revealed that none had a particularly strong influence on the principal findings, with the WMD estimates changing only minimally.

All included studies scored at least an 8 on the methodological quality score, suggesting good quality overall.

“[T]his meta-analysis demonstrates that n-3 LC-PUFAs may have beneficial effect in the older [population] with MCI. And large-scale randomized clinical trials are needed to further confirm our findings,” researchers said.

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Most Read Articles
5 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 6 hours ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

2 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, Yesterday
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.