Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

N-3 long-chain polyunsaturated fatty acid supplements boost cognition in elderly

19 Apr 2020

Elderly adults with mild cognitive impairment (MCI) may derive benefits from N-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), reports a recent meta-analysis.

Researchers performed a comprehensive literature search of the Google Scholar, Embase and PubMed databases. They retrieved seven randomized controlled trials, corresponding to 213 patients on active intervention and 221 on placebo. Studies that combined fatty acids with other interventions, and those that were of other methodological designs, were ineligible.

Across the included studies, the duration of the intervention ranged from 3–24 months. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) doses ranged from 180–1,300 and 40–720 mg, respectively. Outcome was cognitive function, as measured by the mini-mental state examination (MMSE).

Pooled analysis found that n-3 LC-PUFAs had a significant and positive correlation with MMSE cognitive function (weighted mean difference [WMD], 0.85, 95 percent confidence interval, 0.04–1.67; p=0.04). There was slight heterogeneity of evidence, which was of borderline significance (p=0.05).

Sensitivity analysis, carried out by removing studies one at a time, revealed that none had a particularly strong influence on the principal findings, with the WMD estimates changing only minimally.

All included studies scored at least an 8 on the methodological quality score, suggesting good quality overall.

“[T]his meta-analysis demonstrates that n-3 LC-PUFAs may have beneficial effect in the older [population] with MCI. And large-scale randomized clinical trials are needed to further confirm our findings,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.