Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Myocardial injury may be fatal in COVID-19

27 Jul 2020

Among patients with COVID-19, acute myocardial injury occurs commonly, especially in the elderly with pre-existing cardiovascular disease, and is tied to poor prognosis, a study has found.

Researchers looked at the medical records, laboratory results, chest CT images, and medication use in a cohort of 101 patients (median age, 49 years) presenting to two designated COVID-19 treatment centres in Sichuan, China.

Sixteen patients (15.8 percent) had evidence of acute myocardial injury (high-sensitivity troponin T [hs-TnT] >14 pg/mL), with nearly half of them having hs-TnT levels fivefold greater than the normal upper limit.

Patients with vs without acute myocardial injury were older, had a higher prevalence of pre-existing cardiovascular disease (eg, hypertension, coronary artery disease, and cerebrovascular disease), presented with more significant dyspnoea, and were more frequently treated with ACE inhibitor, angiotensin II receptor blocker (ARB), or calcium channel blocker (CCB).

Furthermore, patients with cardiac injury were more likely to require ICU admission (62.5 percent vs 24.7 percent; p=0.003), mechanical ventilation (43.5 percent vs 4.7 percent; p<0.001), and treatment with vasoactive agents (31.2 percent vs 0 percent; p<0.001).

High hs-TnT values were associated with greater disease severity (odds ratio, 6.63, 95 percent confidence interval, 2.24–19.65), and the three cases of deaths all occurred among patients with acute myocardial injury.

The findings underscore the need for targeted treatment and preventative strategies for this vulnerable patient group, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.