Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.

Mycobiome load highest in patients on steroids, antifungal therapy

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

The study included 16 patients with allergic bronchopulmonary aspergillosis (ABPA), 16 with severe asthma with fungal sensitization, nine with severe asthma not sensitized to fungi, seven with mild asthma and 10 healthy controls. Real-time polymerase chain reaction (RT-PCR) was performed after bronchoscopy to determine fungal load.

RT-PCR revealed that a large variability in fungal loads across bronchoalveolar lavage samples, with severe asthmatics showing the greatest fungal levels. Healthy individuals all had low fungal burdens high in Basidiomycete DNA.

In cases where fungal loads were much greater than in healthy controls, Aspergillus fumigatus accounted for the additional burden and formed the largest fungal proportion in patients with disease.

Antifungal therapy with itraconazole appeared to have counterintuitive effects on fungal load in the bronchoalveolar lavage samples. Participants who had never taken the medication had comparable fungal loads to those who were currently on antifungal therapy.

In contrast, those who had prior histories of the medication but had stopped showed the highest burden of fungus. This effect was significant only when compared against participants who were currently on medication (p=0.018). The same was true for A. fumigatus load (p=0.03).

Similarly, ABPA patients receiving corticosteroid therapy also had significantly elevated fungal loads relative to participants not on therapy.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.