Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
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Mycobiome load highest in patients on steroids, antifungal therapy

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

The study included 16 patients with allergic bronchopulmonary aspergillosis (ABPA), 16 with severe asthma with fungal sensitization, nine with severe asthma not sensitized to fungi, seven with mild asthma and 10 healthy controls. Real-time polymerase chain reaction (RT-PCR) was performed after bronchoscopy to determine fungal load.

RT-PCR revealed that a large variability in fungal loads across bronchoalveolar lavage samples, with severe asthmatics showing the greatest fungal levels. Healthy individuals all had low fungal burdens high in Basidiomycete DNA.

In cases where fungal loads were much greater than in healthy controls, Aspergillus fumigatus accounted for the additional burden and formed the largest fungal proportion in patients with disease.

Antifungal therapy with itraconazole appeared to have counterintuitive effects on fungal load in the bronchoalveolar lavage samples. Participants who had never taken the medication had comparable fungal loads to those who were currently on antifungal therapy.

In contrast, those who had prior histories of the medication but had stopped showed the highest burden of fungus. This effect was significant only when compared against participants who were currently on medication (p=0.018). The same was true for A. fumigatus load (p=0.03).

Similarly, ABPA patients receiving corticosteroid therapy also had significantly elevated fungal loads relative to participants not on therapy.

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Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.