Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
28 Nov 2019
Use of stiripentol as an adjunctive treatment in patients with different types of refractory epilepsies, including focal onset epilepsy without bilateral tonic‐clonic seizures, has demonstrated long-term efficacy in a prospective observational study.

Musculoskeletal pain intensity, catastrophizing predict healthcare utilization, opioid use

28 Jul 2020
The opioid epidemic in the US has presented a complicated moral dilemma to doctors when treating potential drug abusers.

Pain intensity and catastrophizing both affect healthcare utilization and costs in patients with musculoskeletal injuries, a recent study has shown.

Researchers enrolled 283 military service members (mean age, 31.85±8.65 years; 92.9 percent male) with musculoskeletal injuries. Participants were made to accomplish a region-specific disability measurement tool, the Pain Catastrophizing Scale (PCS), a numeric pain rating scale, and a body pain diagram. Healthcare cost and utilization, including condition-specific visits and total number of opioid prescriptions, were set as the primary outcome.

Pain intensity was significantly correlated with the number of healthcare visits (β, 0.273, 95 percent confidence interval [CI], 0.034–0.12), while disability was not. Scores on the PCS likewise showed a significant indirect effect on healthcare visits, suggesting that catastrophizing may see partial involvement.

Pain intensity (β, 0.380, 95 percent CI, 0.054–0.706) and disability (β, 0.481, 95 percent CI, 0.072–0.886) were both significantly directly associated with incident opioid use, while pain intensity remained the only factor associated with chronic opioid use (β, 0.366, 95 percent CI, 0.041–0.692). Its effect, however, was indirect. Catastrophizing was not involved in opioid use patterns.

On the other hand, neither pain intensity nor disability predicted total or condition-specific medical costs, while PCS scores did (β, 0.019, 95 percent CI, 0.00–0.041 and β, 0.064, 95 percent CI, 0.011–0.120), albeit only indirectly. Body diagram score showed a similar pattern of effect on accrued costs of care.

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Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
28 Nov 2019
Use of stiripentol as an adjunctive treatment in patients with different types of refractory epilepsies, including focal onset epilepsy without bilateral tonic‐clonic seizures, has demonstrated long-term efficacy in a prospective observational study.