Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Multivessel intervention trumps culprit vessel-only revascularization for NSTE-ACS

04 Nov 2019

Multivessel revascularization (MVR) is better than culprit vessel-only revascularization (CVR) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), reports a recent meta-analysis.

Accessing the databases of PubMed and Embase, researchers identified 15 eligible studies, yielding a pooled sample of 171,279 patients. Of these, majority (n=113,004) underwent CVR while the remaining 58,275 received MVR. Thirteen of the included studies were retrospective in design, while the other two were posthoc analyses of randomized controlled trials.

In the short-term MVR was correlated with a significantly higher prevalence of major adverse cardiovascular events (MACEs; odds ratio [OR], 1.14, 95 percent confidence interval [CI], 1.01–1.29) and a lower likelihood of coronary artery bypass grafting (OR, 0.35, 95 percent CI, 0.29–0.43).

There were no between-intervention differences in terms of all-cause death, myocardial infarction or repeat percutaneous coronary intervention.

Over long-term follow-ups, defined as >6 months after the index procedure, those who received MVR vs CVR were significantly less likely to experience a MACE event (OR, 0.76, 95 percent CI, 0.61–0.93). Similarly, the need to undergo repeat revascularization was significantly lower in the MVR group (OR, 0.62, 95 percent CI, 0.42–0.90), as was the risk of all-cause mortality (OR, 0.83, 95 percent CI, 0.71–0.97).

“There is a high prevalence of multivessel disease in patients who present with NSTE-ACS, and with burgeoning technologies and risk stratification tools, randomized controlled trials are needed,” said researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.