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Stephen Padilla, 3 days ago
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01 Aug 2020
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6 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.

Multiple more effective than single purified protein derivative shot for warts

11 Nov 2019

Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.

The trial randomized 66 patients (mean age, 31 years; 45.45 percent male) with at least three warts in two different anatomic sites to receive a single injection (n=29) and multiple injection (n=29) of PPD. All patients underwent treatment every 2 weeks for a maximum of six sessions.

Clearance rates were more favourable in the group that received multiple vs a single PPD injection (79.3 percent vs 58.6 percent; p=0.0236). Of note, the faster clearance associated with multiple injections was observed at each time point (p=0.048).

Clearance started to become evident at week 4, with the highest clearance rates recorded at week 12 for the single injection group and at week 10 for the multiple injection group. Patients who achieved clearance in both groups did not exhibit any recurrences 6 months after the last injection.

However, multiple injections were reported to be considerably more painful than a single injection (p=0.0005). Safety profiles were similar, with no significant between-group difference in the incidence of adverse events (p=0.1795).

The present data support the results of previous studies on single injections of PPD, although additional studies are warranted to develop a standard protocol for dose and interval of vaccinations, according to the researchers.

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Most Read Articles
Stephen Padilla, 3 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

6 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.