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Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
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Multiple more effective than single purified protein derivative shot for warts

11 Nov 2019

Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.

The trial randomized 66 patients (mean age, 31 years; 45.45 percent male) with at least three warts in two different anatomic sites to receive a single injection (n=29) and multiple injection (n=29) of PPD. All patients underwent treatment every 2 weeks for a maximum of six sessions.

Clearance rates were more favourable in the group that received multiple vs a single PPD injection (79.3 percent vs 58.6 percent; p=0.0236). Of note, the faster clearance associated with multiple injections was observed at each time point (p=0.048).

Clearance started to become evident at week 4, with the highest clearance rates recorded at week 12 for the single injection group and at week 10 for the multiple injection group. Patients who achieved clearance in both groups did not exhibit any recurrences 6 months after the last injection.

However, multiple injections were reported to be considerably more painful than a single injection (p=0.0005). Safety profiles were similar, with no significant between-group difference in the incidence of adverse events (p=0.1795).

The present data support the results of previous studies on single injections of PPD, although additional studies are warranted to develop a standard protocol for dose and interval of vaccinations, according to the researchers.

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Most Read Articles
Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 5 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.