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Multimorbidity tied to more severe disease in axSpA patients

10 Feb 2020
Three conditions that require physical therapy

Patients with axial spondyloarthropathy (axSpA) are at greater risk of multimorbidity, which also happens to exacerbate the disease, reports a study.

Of the 734 patients (mean age, 45 years; 77 percent male) recruited from 12 centres, 403 (55 percent) were multimorbid. Patients with multimorbidity tended to be older than axSpA-only patients (50 vs 40 years; p<0.01). the most common chronic condition was obesity, which affected nearly one in four patients (27 percent). Multimorbid patients also had more severe disease than those with axSpA only.

After adjusting for confounders, multimorbidity was found to be associated with the higher scores in the following measures: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; ß, 0.7, 95 percent confidence interval [CI], 0.34–1.05), Bath AS Metrology Index (BASMI; ß, 0.45, 95 percent CI, 0.09–0.80), Bath AS Functional Index (BASFI; ß, 0.5, 95 percent CI, 0.23–0.78), Health Assessment Questionnaire HAQ (ß, 0.07, 95 percent CI, 0.00–0.13), and AS Quality of Life (ASQoL; ß, 0.87, 95 percent, CI 0.28–1.46).

This cross-sectional study was carried out within the Ankylosing Spondylitis Registry of Ireland cohort. The authors conducted structured standardized assessment. Multimorbidity was defined as the presence of at least one physician-diagnosed chronic condition, except extra-articular manifestations, in addition to axSpA.

The following validated outcome measures were obtained: BASDAI, BASFI, HAQ, ASQoL and BASMI. The association between multimorbidity and disease outcomes were examined using adjusted multiple regression.

“Multimorbidity, the coexistence of two or more conditions in an individual, is associated with morbidity and mortality in the general population,” the authors noted.

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Most Read Articles
Elvira Manzano, 3 days ago
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, 3 days ago
For individuals with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
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