Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 17 hours ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 6 days ago
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.

Mucosal melanoma stage, site predict patient survival

26 Jun 2019

Tumour stage and anatomic site significantly affect the prognosis of mucosal melanomas, while patient demographics and tumour thickness do not, a recent study has found.

Accessing the California Cancer Registry, researchers analysed 132,751 melanoma cases, of which 1.4 percent (n=1,824) were of mucosal melanoma. Majority of the cases (98.6 percent; n=130,927) were cutaneous in nature. The 5-year survival estimate was significantly lower for mucosal vs cutaneous melanoma patients (27.64 percent vs 76.28 percent).

Regardless of cancer type, stage at diagnosis was also a significant predictor of survival. Five-year estimates were worse for those with remotely (13.50 percent) and regionally (50.85 percent) metastasized cutaneous melanoma, as opposed to those with only localized metastases (82.87 percent).

The same pattern was true for mucosal melanoma patients (localized: 43.93 percent; regional: 18.76 percent; remote: 7.84 percent). Notably, 5-year survival estimates for localized mucosal melanoma was lower than cutaneous melanoma with regional metastasis.

The anatomic tumour site likewise emerged as a significant prognostic factor. Five-year survival estimates for the genitourinary, oral cavity, nasal and sinus, gastrointestinal, and anorectal malignancies were 37.41 percent, 27.85 percent, 23.77 percent, 20.94 percent and 16.68 percent, respectively. The estimate for melanomas occurring in other sites was 13.57 percent.

Multivariate Cox proportional hazards regression analysis further confirmed that stage at diagnosis was a significant predictor of survival in both cutaneous (distant vs local metastasis: hazard ratio [HR], 7.64, 95 percent CI, 7.37–7.92) and mucosal (HR, 3.36, 2.9–3.92) melanomas.

Similarly, mucosal melanomas occurring at less common primary sites (spine, lung and pleura, liver, and pancreas: HR, 1.93, 1.41–2.64) also posed an increased risk of death, as did oral, anorectal and gastrointestinal mucosal melanomas.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 17 hours ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 6 days ago
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.