Most Read Articles
19 Sep 2018
In advanced-stage, newly diagnosed classical, CD30-positive Hodgkin lymphoma (HL), front-line therapy has resulted in durable remission rates in up to 70–90% of patients, although approximately 25–30% of advanced stage HL patients are refractory or relapse following first-line treatment with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) chemotherapy.1–3 The standard of care for patients with relapsed or refractory (r/r) classical HL is salvage therapy using second-line high-dose chemotherapy (HDCT), followed by autologous haematopoietic stem cell transplant (ASCT) in eligible patients, which can induce a complete remission (CR) in about 50% of patients.4 Nevertheless, the prognosis of patients who relapse after the salvage HDCT/ASCT is exceedingly poor, with a median survival duration of approximately 1.2 years.5
Elaine Soliven, 28 Jun 2019
Adjuvant treatment with ipilimumab significantly improved overall survival (OS) among patients with resected high-risk melanoma compared with high-dose interferon-α2b (HDI*), according to final results of the North American Intergroup E1609** trial presented at ASCO 2019.
Elaine Soliven, 18 Jun 2019
Neoadjuvant treatment with trastuzumab emtansine (T-DM1) plus pertuzumab led to an elevated risk of 3-year event-free survival (EFS) events in patients with HER2-positive breast cancer, according to a secondary analysis of the KRISTINE* trial presented at ASCO 2019.
Audrey Abella, 11 Jul 2019
Augmenting the triple chemotherapeutic regimen FOLFOXIRI* with bevacizumab demonstrated favourable efficacy regardless of age and gender in patients with unresectable metastatic colorectal cancer (mCRC), according to data presented at the ESMO World Congress on Gastrointestinal Cancer (ESMO GI) 2019.

MRI, post-MRI biopsy drive decision making in newly diagnosed favourable-risk prostate cancer

16 Apr 2019

Decision making in men with newly diagnosed favourable-risk prostate cancer is driven by magnetic resonance imaging (MRI) and post-MRI biopsy, according to a study, noting that post-MRI biopsy is a stronger driver of decision making than MRI alone.

“This was demonstrated by the >90 percent of men with reassuring post-MRI biopsies who elected active surveillance regardless of MRI results,” the authors said.

A total of 1,461 men with favourable-risk prostate cancer were included. Of these, 1,223 (84 percent) did not undergo MRI, 157 (11 percent) underwent MRI alone, and 81 (6 percent) underwent MRI and post-MRI biopsy.

There were more men with reassuring findings than those with nonreassuring or MRI findings who elected active surveillance (74 percent vs 35 percent and 42 percent, respectively) among patients who underwent MRI alone.

Furthermore, men with reassuring post-MRI biopsy had the highest rate of active surveillance regardless of whether MRI was reassuring or nonreassuring (93 percent and 96 percent, respectively).

The authors reviewed the records of men with newly diagnosed favourable risk prostate cancer in the Michigan Urological Surgery Improvement Collaborative. These men were classified into three groups following diagnostic biopsy: group 1, no MRI; group 2, MRI only; group 3, MRI/post-MRI biopsy.

MRI results were deemed reassuring (Prostate Imaging Reporting and Data System [PI-RADS] 3) or nonreassuring (PI-RADS 4) for purposes of counselling and shared decision making.

Additionally, if the diagnostic biopsy was grade group (GG) 1, post-MRI biopsy results were considered nonreassuring should there be any amount of GG 2. If the diagnostic biopsy was GG 2, post-MRI biopsy results were deemed nonreassuring if more than three cores were GG 2, or there was >50-percent GG2 in any individual core or any volume of GG 3.

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Most Read Articles
19 Sep 2018
In advanced-stage, newly diagnosed classical, CD30-positive Hodgkin lymphoma (HL), front-line therapy has resulted in durable remission rates in up to 70–90% of patients, although approximately 25–30% of advanced stage HL patients are refractory or relapse following first-line treatment with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) chemotherapy.1–3 The standard of care for patients with relapsed or refractory (r/r) classical HL is salvage therapy using second-line high-dose chemotherapy (HDCT), followed by autologous haematopoietic stem cell transplant (ASCT) in eligible patients, which can induce a complete remission (CR) in about 50% of patients.4 Nevertheless, the prognosis of patients who relapse after the salvage HDCT/ASCT is exceedingly poor, with a median survival duration of approximately 1.2 years.5
Elaine Soliven, 28 Jun 2019
Adjuvant treatment with ipilimumab significantly improved overall survival (OS) among patients with resected high-risk melanoma compared with high-dose interferon-α2b (HDI*), according to final results of the North American Intergroup E1609** trial presented at ASCO 2019.
Elaine Soliven, 18 Jun 2019
Neoadjuvant treatment with trastuzumab emtansine (T-DM1) plus pertuzumab led to an elevated risk of 3-year event-free survival (EFS) events in patients with HER2-positive breast cancer, according to a secondary analysis of the KRISTINE* trial presented at ASCO 2019.
Audrey Abella, 11 Jul 2019
Augmenting the triple chemotherapeutic regimen FOLFOXIRI* with bevacizumab demonstrated favourable efficacy regardless of age and gender in patients with unresectable metastatic colorectal cancer (mCRC), according to data presented at the ESMO World Congress on Gastrointestinal Cancer (ESMO GI) 2019.