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Mortality up in SLE patients a month after ischaemic stroke

09 Nov 2017

Patients with systemic lupus erythematosus (SLE), compared to those without, have an increased risk of mortality after the first month following an ischaemic stroke, a recent study has found. In addition, functionality becomes poorer at 3 months.

To examine mortality and functionality impairment after stroke in SLE, researchers identified 423 patients with SLE and 1,652 individuals with SLE who developed a first-ever ischaemic or haemorrhagic stroke (1998 to 2013) using Swedish nationwide registers. Patients were followed for 1 year or until all-cause death.

Researchers then estimated the hazard ratio (HR) for death after ischaemic or haemorrhagic stroke and the risk ratio (RR) of functional impairment (dependence in either transferring, toileting or dressing) 3 months following ischaemic stroke.

Twenty-two percent of patients with SLE died a year after stroke compared with 16 percent of those without SLE. There was an increased risk of death for patients with SLE after ischaemic stroke (HR, 1.85; 95 percent CI, 1.39 to 2.45), which was attenuated after controlling for SLE-related comorbidities (HR, 1.41; 1.04 to 1.91).

Furthermore, functional impairment at 3 months increased by almost twofold in patients with SLE (RR, 1.73; 1.16 to 2.57). Those with SLE had an HR for death of 2.30 (1.38 to 3.82) following haemorrhagic stroke, which was elevated even during the first month.

“SLE is associated with all-cause death after haemorrhagic stroke even during the first month,” according to researchers, adding that there is a need for “a shift of focus to patient functionality and prevention of haemorrhagic strokes.”

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 5 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
4 days ago
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.