Most Read Articles
01 May 2014

New drug applications approved by US FDA as of 15-30 May which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

12 Apr 2017
Patients with fibromyalgia syndrome (FMS) are at an increased risk of peptic ulcer disease (PUD), a new study shows.
08 May 2017
Transabdominal bowel wall ultrasonography shows utility in monitoring disease activity in patients with active Crohn’s disease (CD), according to a study. The imaging technique is ideal for evaluating early transmural changes in disease activity, in response to medical treatment.
01 Jun 2015
A mixture of the flavonoids diosmin, troxerutin, and hesperidin is safe and effective for the symptomatic management of patients with acute haemorrhoidal disease, a prospective, randomised, triple-blind, controlled trial revealed.

Morning placement of 48-hour wireless capsule results in less reflux

23 Jul 2017

Afternoon placement of the 48-hour wireless ambulatory pH capsule has significantly increased the amount of acid reflux on the first day, a recent study has found.

“Approximately 10 percent of the 48-hour oesophageal wireless monitoring studies may falsely overestimate reflux when the capsule is placed in the afternoon,” researchers said.

A retrospective cohort study was conducted to investigate the differences in data obtained on day 1 vs day 2, and the effect of time of capsule placement on discrepancies. Included were patients (n=229) undergoing a 48-hour wireless capsule study between January 2012 through November 2013.

Researchers collected reflux data for each patient and calculated the proportion of patients in four groups based on abnormal DeMeester score groups (+/+, −/+, +/−, −/−). Participants were assigned to morning or afternoon placement categories, and the proportions of patients with different DeMeester score discrepancies were calculated.

The mean DeMeester scores were 28.38 for day 1 and 23.24 for day 2 (p<0.0001). For day 1, the mean DeMeester score in the morning group was 24.9 and in the afternoon group 31.7 (p<0.05). The mean total DeMeester scores in the morning and afternoon placement groups were 23.1 and 30.6, respectively (p<0.05).

A +day 1/−day 2 DeMeester discordance was observed in 25 percent of afternoon patients, while such discordance was seen in only 12 percent of morning placement patients (p=0.26).

These findings suggest that placement of 48-hour wireless capsules should ideally be performed in the morning, according to researchers.

“A 48-hour wireless capsule results often vary from the first to second day. Previous investigations comparing discrepant acid reflux readings have yielded variable results,” researchers noted.

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Most Read Articles
01 May 2014

New drug applications approved by US FDA as of 15-30 May which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

12 Apr 2017
Patients with fibromyalgia syndrome (FMS) are at an increased risk of peptic ulcer disease (PUD), a new study shows.
08 May 2017
Transabdominal bowel wall ultrasonography shows utility in monitoring disease activity in patients with active Crohn’s disease (CD), according to a study. The imaging technique is ideal for evaluating early transmural changes in disease activity, in response to medical treatment.
01 Jun 2015
A mixture of the flavonoids diosmin, troxerutin, and hesperidin is safe and effective for the symptomatic management of patients with acute haemorrhoidal disease, a prospective, randomised, triple-blind, controlled trial revealed.